CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035911
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha actinin 4 short isoform 
Protein Synonyms/Alias
 Alpha-actinin-4 
Gene Name
 ACTN4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
112TIQEMQQKLEDFRDYubiquitination[1]
385IAESNHIKLSGSNPYubiquitination[1]
403TPQIINSKWEKVQQLubiquitination[1]
406IINSKWEKVQQLVPKacetylation[2]
406IINSKWEKVQQLVPKubiquitination[1, 3]
413KVQQLVPKRDHALLEubiquitination[3]
640FKVLAGDKNFITAEEubiquitination[3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 692 AA 
Protein Sequence
MVDYHAANQS YQYGPSSAGN GAGGGGSMGD YMAQEDDWDR DLLLDPAWEK QQRKAETAAN 60
RICKVLAVNQ ENEHLMEDYE KLASDLLEWI RRTIPWLEDR VPQKTIQEMQ QKLEDFRDYR 120
RVHKPPKVQE KCQLEINFNT LQTKLRLSNR PAFMPSEGKM VSDINNGWQH LEQAEKGYEE 180
WLLNEIRRLE RLDHLAEKFR QKASIHEAWT DGKEAMLKHR DYETATLSDI KALIRKHEAF 240
ESDLAAHQDR VEQIAAIAQE LNELDYYDSH NVNTRCQKIC DQWDALGSLT HSRREALEKT 300
EKQLEAIDQL HLEYAKRAAP FNNWMESAME DLQDMFIVHT IEEIEGLISA HDQFKSTLPD 360
ADREREAILA IHKEAQRIAE SNHIKLSGSN PYTTVTPQII NSKWEKVQQL VPKRDHALLE 420
EQSKQQSNEH LRRQFASQAN VVGPWIQTKM EEIGRISIEM NGTLEDQLSH LKQYERSIVD 480
YKPNLDLLEQ QHQLIQEALI FDNKHTNYTM EHIRVGWEQL LTTIARTINE VENQILTRDA 540
KGISQEQMQE FRASFNHFDK DHGGALGPEE FKACLISLGY DVENDRQGEA EFNRIMSLVD 600
PNHSGLVTFQ AFIDFMSRET TDTDTADQVI ASFKVLAGDK NFITAEELRR ELPPDQAEYC 660
IARMAPYQGP DAVPGALDYK SFSTALYGES DL 692 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0051764; P:actin crosslink formation; IEA:InterPro.
 GO:0051017; P:actin filament bundle assembly; IEA:InterPro. 
Interpro
 IPR026921; Alpha-actinin.
 IPR011992; EF-hand-like_dom.
 IPR014837; EF-hand_Ca_insen.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF13405; EF_hand_4
 PF08726; efhand_Ca_insen
 PF00435; Spectrin 
SMART
 SM00054; EFh
 SM00150; SPEC 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS