CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024103
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fructose-1,6-bisphosphatase isozyme 2 
Protein Synonyms/Alias
 FBPase 2; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 
Gene Name
 Fbp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
208IRIKKKGKIFSLNEGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 NP_BIND 18 22 AMP (By similarity).
 NP_BIND 28 32 AMP (By similarity).
 NP_BIND 113 114 AMP (By similarity).
 REGION 122 125 Substrate binding (By similarity).
 REGION 213 216 Substrate binding (By similarity).
 REGION 244 249 Substrate binding (By similarity).
 REGION 275 277 Substrate binding (By similarity).
 METAL 69 69 Magnesium 1 (By similarity).
 METAL 98 98 Magnesium 1 (By similarity).
 METAL 98 98 Magnesium 2 (By similarity).
 METAL 119 119 Magnesium 2 (By similarity).
 METAL 119 119 Magnesium 3 (By similarity).
 METAL 121 121 Magnesium 2; via carbonyl oxygen (By
 METAL 122 122 Magnesium 3 (By similarity).
 METAL 281 281 Magnesium 3 (By similarity).
 BINDING 141 141 AMP (By similarity).
 BINDING 265 265 Substrate (By similarity).  
Keyword
 Allosteric enzyme; Carbohydrate metabolism; Complete proteome; Gluconeogenesis; Hydrolase; Magnesium; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 339 AA 
Protein Sequence
MTDRSPFETD MLTLTRYVME KGRQAKGTGE LTQLLNSMLT AIKAISSAVR KAGLANLYGI 60
AGSVNVTGDE VKKLDVLSNS LVINMLQSSY STCVLVSEEN KEAVITAKER RGKYVVCFDP 120
LDGSSNIDCL ASIGTIFAIY RKTTEDEPSE KDALQPGRNI VAAGYALYGS ATLVALSTGQ 180
GVDLFMLDPA LGEFVLVEKD IRIKKKGKIF SLNEGYAKYF DAATAEYVQK KKFPEDGSAP 240
YGARYVGSMV ADVHRTLVYG GIFMYPANQK SPNGKLRLLY ECNPVAYIIE QAGGMATTGT 300
QPVLDVKPES IHQRVPLILG SPEDVQEYLS CVQRNQAGR 339 
Gene Ontology
 GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006094; P:gluconeogenesis; IDA:RGD. 
Interpro
 IPR000146; FBPase_class-1/SBPase.
 IPR020548; Fructose_bisphosphatase_AS. 
Pfam
 PF00316; FBPase 
SMART
  
PROSITE
 PS00124; FBPASE 
PRINTS
 PR00115; F16BPHPHTASE.