UniProt Accession

 GBRB3_HUMAN; P28472; B7Z2W1; B7Z825; F5H3D2; H7BYV8; Q14352; Q96FM5 

Genbank Protein ID

 M82919; AK295167; AK302822; AC009878; AC011196; AC104569; AC127511; AC135999; AC145167; AC145196; EU606048; CH471151; BC010641; L04311; L04311 

Genbank Nucleotide ID

 AAA52511.1; BAH11997.1; BAH13811.1; EAW57655.1; AAH10641.1; AAA52508.1; AAA52507.1 

Protein Name

 Gamma-aminobutyric acid receptor subunit beta-3 

Protein Synonyms/Alias

 GABA(A) receptor subunit beta-3 

Gene Name

 GABRB3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
46	ETVDKLLKGYDIRLR	ubiquitination	[1]
127	DTYFLNDKKSFVHGV	ubiquitination	[1]
137	FVHGVTVKNRMIRLH	ubiquitination	[1]
198	FYWRGGDKAVTGVER	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 

Sequence Annotation

 CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
 CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
 DISULFID 161 175 By similarity.  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disease mutation; Disulfide bond; Epilepsy; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 473 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
 GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
 GO:0004890; F:GABA-A receptor activity; TAS:ProtInc.
 GO:0090102; P:cochlea development; IEA:Compara.
 GO:0060119; P:inner ear receptor cell development; IEA:Compara.
 GO:0060384; P:innervation; IEA:Compara.
 GO:0034220; P:ion transmembrane transport; TAS:Reactome.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR006028; GABAA_rcpt.
 IPR002289; GABAAb_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 

Pfam

 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR01160; GABAARBETA.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.