CPLM-024130

Genbank Nucleotide ID

Homer protein homolog 1

Protein Synonyms/Alias

PSD-Zip45; VASP/Ena-related gene up-regulated during seizure and LTP 1; Vesl-1

Rattus norvegicus (Rat)

Position	Peptide	Type	References
98	SSEHHLSKFAEKFQE	acetylation	[1]
102	HLSKFAEKFQEFKEA	acetylation	[1]
208	TLKGNNAKLTAALLE	ubiquitination	[2]
221	LESTANVKQWKQQLA	ubiquitination	[2]
302	QRDSLTQKLQEVEIR	acetylation	[1]
311	QEVEIRNKDLEGQLS	ubiquitination	[2]

[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
[2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]

Functional Description

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

3D-structure; Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0045177; C:apical part of cell; IEA:Compara.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0043034; C:costamere; IEA:Compara.
GO:0043198; C:dendritic shaft; IDA:RGD.
GO:0043025; C:neuronal cell body; IDA:RGD.
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
GO:0014069; C:postsynaptic density; IDA:BHF-UCL.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0030018; C:Z disc; IEA:Compara.
GO:0005102; F:receptor binding; IDA:RGD.
GO:0048148; P:behavioral response to cocaine; IEA:Compara.
GO:0048875; P:chemical homeostasis within a tissue; IEA:Compara.
GO:0007623; P:circadian rhythm; IEP:RGD.
GO:0007216; P:G-protein coupled glutamate receptor signaling pathway; IDA:RGD.
GO:0051928; P:positive regulation of calcium ion transport; IEA:Compara.
GO:0035418; P:protein localization to synapse; IDA:BHF-UCL.
GO:0090279; P:regulation of calcium ion import; IEA:Compara.
GO:2001257; P:regulation of cation channel activity; IEA:Compara.
GO:2001256; P:regulation of store-operated calcium entry; IEA:Compara.
GO:0051592; P:response to calcium ion; IEA:Compara.
GO:0042220; P:response to cocaine; IEP:RGD.
GO:0035094; P:response to nicotine; IEP:RGD.
GO:0003009; P:skeletal muscle contraction; IEA:Compara.
GO:0048741; P:skeletal muscle fiber development; IEA:Compara.

IPR000697; EVH1.
IPR011993; PH_like_dom.