CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044657
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytosine-specific methyltransferase 
Protein Synonyms/Alias
  
Gene Name
 Dnmt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
550CQQPECGKCKACKDMubiquitination[1]
555CGKCKACKDMVKFGGubiquitination[1]
866RKYSDYIKGSNLDAPubiquitination[1]
995RSPGNKGKGKGKGKGacetylation[2]
997PGNKGKGKGKGKGKGacetylation[2]
999NKGKGKGKGKGKGKHacetylation[2]
1003GKGKGKGKGKHQVSEacetylation[2, 3]
1005GKGKGKGKHQVSEPKacetylation[2, 3]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1501 AA 
Protein Sequence
MADSNRSPRS RPKPRGPRRS KSDSDTLFET SPSSVATRRT TRQTTITAHF TKGPTKRKPK 60
EESEEGNSAE SAAEERDQDK KRRVVDTESG AAAAVEKLEE VTAGTQLGPE EPCEQEDDNR 120
SLRRHTRELS LRRKSKEDPD REARPETHLD EDEDGKKDKR SSRPRSQPRD PAAKRRPKEA 180
EPEQVAPETP EDRDEDEREE KRRKTTRKKL ESHTVPVQSR SERKAAQSKS VIPKINSPKC 240
PECGQHLDDP NLKYQQHPED AVDEPQMLTS EKLSIYDSTS TWFDTYEDSP MHRFTSFSVY 300
CSRGHLCPVD TGLIEKNVEL YFSGCAKAIH DENPSMEGGI NGKNLGPINQ WWLSGFDGGE 360
KVLIGFSTAF AEYILMEPSK EYEPIFGLMQ EKIYISKIVV EFLQNNPDAV YEDLINKIET 420
TVPPSTINVN RFTEDSLLRH AQFVVSQVES YDEAKDDDET PIFLSPCMRA LIHLAGVSLG 480
QRRATRRVMG ATKEKDKAPT KATTTKLVYQ IFDTFFSEQI EKYDKEDKEN AMKRRRCGVC 540
EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADDDEEAD DDVSEMPSPK 600
KLHQGKKKKQ NKDRISWLGQ PMKIEENRTY YQKVSIDEEM LEVGDCVSVI PDDSSKPLYL 660
ARVTALWEDK NGQMMFHAHW FCAGTDTVLG ATSDPLELFL VGECENMQLS YIHSKVKVIY 720
KAPSENWAME GGTDPETTLP GAEDGKTYFF QLWYNQEYAR FESPPKTQPT EDNKHKFCLS 780
CIRLAELRQK EMPKVLEQIE EVDGRVYCSS ITKNGVVYRL GDSVYLPPEA FTFNIKVASP 840
VKRPKKDPVN ETLYPEHYRK YSDYIKGSNL DAPEPYRIGR IKEIHCGKKK GKVNEADIKL 900
RLYKFYRPEN THRSYNGSYH TDINMLYWSD EEAVVNFSDV QGRCTVEYGE DLLESIQDYS 960
QGGPDRFYFL EAYNSKTKNF EDPPNHARSP GNKGKGKGKG KGKGKHQVSE PKEPEAAIKL 1020
PKLRTLDVFS GCGGLSEGFH QAGISETLWA IEMWDPAAQA FRLNNPGTTV FTEDCNVLLK 1080
LVMAGEVTNS LGQRLPQKGD VEMLCGGPPC QGFSGMNRFN SRTYSKFKNS LVVSFLSYCD 1140
YYRPRFFLLE NVRNFVSYRR SMVLKLTLRC LVRMGYQCTF GVLQAGQYGV AQTRRRAIIL 1200
AAAPGEKLPL FPEPLHVFAP RACQLSVVVD DKKFVSNITR LSSGPFRTIT VRDTMSDLPE 1260
IQNGASNSEI PYNGEPLSWF QRQLRGSHYQ PILRDHICKD MSPLVAARMR HIPLFPGSDW 1320
RDLPNIQVRL GDGVIAHKLQ YTFHDVKNGY SSTGALRGVC SCAEGKACDP ESRQFSTLIP 1380
WCLPHTGNRH NHWAGLYGRL EWDGFFSTTV TNPEPMGKQG RVLHPEQHRV VSVRECARSQ 1440
GFPDSYRFFG NILDRHRQVG NAVPPPLAKA IGLEIKLCLL SSARESASAA VKAKEEAATK 1500
D 1501 
Gene Ontology
 GO:0000792; C:heterochromatin; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005657; C:replication fork; IDA:MGI.
 GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IDA:MGI.
 GO:0008327; F:methyl-CpG binding; IDA:MGI.
 GO:0003723; F:RNA binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IDA:MGI.
 GO:0071230; P:cellular response to amino acid stimulus; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0042127; P:regulation of cell proliferation; IGI:MGI. 
Interpro
 IPR001025; BAH_dom.
 IPR018117; C5_DNA_meth_AS.
 IPR001525; C5_MeTfrase.
 IPR022702; Cytosine_MeTrfase1_RFD.
 IPR017198; DNA_C5-MeTrfase_1_euk.
 IPR002857; Znf_CXXC. 
Pfam
 PF01426; BAH
 PF00145; DNA_methylase
 PF12047; DNMT1-RFD
 PF02008; zf-CXXC 
SMART
 SM00439; BAH 
PROSITE
 PS51038; BAH
 PS00094; C5_MTASE_1
 PS00095; C5_MTASE_2
 PS51058; ZF_CXXC 
PRINTS
 PR00105; C5METTRFRASE.