UniProt Accession

 PAG15_HUMAN; Q8NCC3; B3KMF3; Q53GZ1; Q9NPQ6; Q9UG04; Q9Y2B3 

Genbank Protein ID

 AB017494; AY358425; AK001705; AK074828; AK222790; AL110209; CH471092; BC011640; BC062605; AL389957 

Genbank Nucleotide ID

 BAA76877.1; AAQ88791.1; BAG50965.1; BAC11233.1; BAD96510.1; CAB53675.1; EAW83217.1; AAH11640.2; AAH62605.1; CAB97531.1 

Protein Name

 Group XV phospholipase A2 

Protein Synonyms/Alias

 1-O-acylceramide synthase; ACS; LCAT-like lysophospholipase; LLPL; Lysophospholipase 3; Lysosomal phospholipase A2; LPLA2 

Gene Name

 PLA2G15 

Gene Synonyms/Alias

 LYPLA3; UNQ341/PRO540 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	NIRLVYNKTSRATQF	ubiquitination	[1]
120	VRVPGFGKTFSLEFL	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid (By similarity). May have weak lysophospholipase activity. 

Sequence Annotation

 ACT_SITE 198 198 Acyl-ester intermediate (Potential).
 ACT_SITE 360 360 Charge relay system (By similarity).
 ACT_SITE 392 392 Charge relay system (By similarity).
 CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).
 CARBOHYD 273 273 N-linked (GlcNAc...) (Potential).
 CARBOHYD 289 289 N-linked (GlcNAc...) (Potential).
 CARBOHYD 398 398 N-linked (GlcNAc...) (Potential).  

Keyword

 Acyltransferase; Complete proteome; Direct protein sequencing; Fatty acid metabolism; Glycoprotein; Hydrolase; Lipid metabolism; Lysosome; Reference proteome; Secreted; Signal; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0047499; F:calcium-independent phospholipase A2 activity; ISS:UniProtKB.
 GO:0004622; F:lysophospholipase activity; TAS:ProtInc.
 GO:0008374; F:O-acyltransferase activity; ISS:UniProtKB.
 GO:0005543; F:phospholipid binding; TAS:ProtInc.
 GO:0006672; P:ceramide metabolic process; IEA:Compara.
 GO:0009062; P:fatty acid catabolic process; TAS:ProtInc.
 GO:0046470; P:phosphatidylcholine metabolic process; IEA:Compara. 

Interpro

 IPR003386; LACT/PDAT_acylTrfase. 

Pfam

 PF02450; LACT 

SMART

  

PROSITE

  

PRINTS