CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022079
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 277 
Protein Synonyms/Alias
 Nuclear receptor-interacting factor 4 
Gene Name
 ZNF277 
Gene Synonyms/Alias
 NRIF4; ZNF277P 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MAASKTQGAVARubiquitination[1]
152ILREELQKQRLREILubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 224 248 C2H2-type 1.
 ZN_FING 355 381 C2H2-type 2.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MAASKTQGAV ARMQEDRDGS CSTVGGVGYG DSKDCILEPL SLPESPGGTT TLEGSPSVPC 60
IFCEEHFPVA EQDKLLKHMI IEHKIVIADV KLVADFQRYI LYWRKRFTEQ PITDFCSVIR 120
INSTAPFEEQ ENYFLLCDVL PEDRILREEL QKQRLREILE QQQQERNDTN FHGVCMFCNE 180
EFLGNRSVIL NHMAREHAFN IGLPDNIVNC NEFLCTLQKK LDNLQCLYCE KTFRDKNTLK 240
DHMRKKQHRK INPKNREYDR FYVINYLELG KSWEEVQLED DRELLDHQED DWSDWEEHPA 300
SAVCLFCEKQ AETIEKLYVH MEDAHEFDLL KIKSELGLNF YQQVKLVNFI RRQVHQCRCY 360
GCHVKFKSKA DLRTHMEETK HTSLLPDRKT WDQLEYYFPT YENDTLLCTL SDSESDLTAQ 420
EQNENVPIIS EDTSKLYALK QSSILNQLLL 450 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS