UniProt Accession

 LAIR1_HUMAN; Q6GTX8 

Genbank Protein ID

 AF013249; AF109683; AF251509; AF251510; CR542051; BC027899 

Genbank Nucleotide ID

 AAB69324.1; AAF17107.1; AAF71274.2; AAF71275.2; CAG46848.1; AAH27899.1 

Protein Name

 Leukocyte-associated immunoglobulin-like receptor 1 

Protein Synonyms/Alias

 LAIR-1; hLAIR1; CD305 

Gene Name

 LAIR1 

Gene Synonyms/Alias

 CD305 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
200	KQGPPRSKDEEQKPQ	ubiquitination	[1]
205	RSKDEEQKPQQRPDL	ubiquitination	[1]
273	AVSPQSTKPMAESIT	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. 

Sequence Annotation

 DOMAIN 29 117 Ig-like C2-type.
 MOTIF 249 254 ITIM motif 1.
 MOTIF 279 284 ITIM motif 2.
 MOD_RES 251 251 Phosphotyrosine.
 MOD_RES 281 281 Phosphotyrosine.
 CARBOHYD 69 69 N-linked (GlcNAc...).
 DISULFID 49 101  

Keyword

 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 287 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:HPA. 

Interpro

 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub. 

Pfam

  

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS