CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ras GTPase-activating protein-binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 G3BP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
171NLPHEVDKSELKDFFacetylation[1, 2]
194LRINSGGKLPNFGFVacetylation[2, 3, 4]
194LRINSGGKLPNFGFVubiquitination[4, 5, 6, 7]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MEEHLEEPVA EPEPDPEPEP EQEPVSEIQE EKPEPVLEET APEDAQKSSS PAPADIAQTV 60
QEDLRTFSWA SVTSKNLPPS GAVPVTGIPP HVVKVPASQP RPESKPESQI PPQRPQRDQR 120
VREQRINIPP QRGPRPIREA GEQGDIEPRR MVRHPDSHQL FIGNLPHEVD KSELKDFFQS 180
YGNVVELRIN SGGKLPNFGF VVFDDSEPVQ KVLSNRPIMF RGEVRLNVEE KKTRAAREGD 240
RRDNRLRGPG GPRGGLGGGM RGPPRGGMVQ KPGFGVGRGL APRQ 284 
Gene Ontology
 GO:0010494; C:cytoplasmic stress granule; IEA:Compara.
 GO:0003729; F:mRNA binding; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS