CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018790
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 A-kinase anchor protein 1, mitochondrial 
Protein Synonyms/Alias
 A-kinase anchor protein 149 kDa; AKAP 149; Dual specificity A-kinase-anchoring protein 1; D-AKAP-1; Protein kinase A-anchoring protein 1; PRKA1; Spermatid A-kinase anchor protein 84; S-AKAP84 
Gene Name
 AKAP1 
Gene Synonyms/Alias
 AKAP149; PRKA1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
589DSCCSLKKTESFQNAubiquitination[1]
634GRYVSFLKQTSGAKIubiquitination[1]
676NLIGKKFKELNLTNIubiquitination[2]
800YVDYGGYKRVKVDVLubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. 
Sequence Annotation
 DOMAIN 607 671 KH.
 DOMAIN 758 817 Tudor.
 REGION 344 357 PKA-RII subunit binding domain.
 MOD_RES 70 70 Phosphothreonine.
 MOD_RES 105 105 Phosphoserine (By similarity).
 MOD_RES 107 107 Phosphoserine (By similarity).
 MOD_RES 169 169 Phosphoserine.
 MOD_RES 429 429 Phosphoserine.
 MOD_RES 447 447 Phosphothreonine.
 MOD_RES 533 533 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Transit peptide; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 903 AA 
Protein Sequence
MAIQFRSLFP LALPGMLALL GWWWFFSRKK GHVSSHDEQQ VEAGAVQLRA DPAIKEPLPV 60
EDVCPKVVST PPSVTEPPEK ELSTVSKLPA EPPALLQTHP PCRRSESSGI LPNTTDMRLR 120
PGTRRDDSTK LELALTGGEA KSIPLECPLS SPKGVLFSSK SAEVCKQDSP FSRVPRKVQP 180
GYPVVPAEKR SSGERARETG GAEGTGDAVL GEKVLEEALL SREHVLELEN SKGPSLASLE 240
GEEDKGKSSS SQVVGPVQEE EYVAEKLPSR FIESAHTELA KDDAAPAPPV ADAKAQDRGV 300
EGELGNEESL DRNEEGLDRN EEGLDRNEES LDRNEEGLDR NEEIKRAAFQ IISQVISEAT 360
EQVLATTVGK VAGRVCQASQ LQGQKEESCV PVHQKTVLGP DTAEPATAEA AVAPPDAGLP 420
LPGLPAEGSP PPKTYVSCLK SLLSSPTKDS KPNISAHHIS LASCLALTTP SEELPDRAGI 480
LVEDATCVTC MSDSSQSVPL VASPGHCSDS FSTSGLEDSC TETSSSPRDK AITPPLPEST 540
VPFSNGVLKG ELSDLGAEDG WTMDAEADHS GGSDRNSMDS VDSCCSLKKT ESFQNAQAGS 600
NPKKVDLIIW EIEVPKHLVG RLIGKQGRYV SFLKQTSGAK IYISTLPYTQ SVQICHIEGS 660
QHHVDKALNL IGKKFKELNL TNIYAPPLPS LALPSLPMTS WLMLPDGITV EVIVVNQVNA 720
GHLFVQQHTH PTFHALRSLD QQMYLCYSQP GIPTLPTPVE ITVICAAPGA DGAWWRAQVV 780
ASYEETNEVE IRYVDYGGYK RVKVDVLRQI RSDFVTLPFQ GAEVLLDSVM PLSDDDQFSP 840
EADAAMSEMT GNTALLAQVT SYSPTGLPLI QLWSVVGDEV VLINRSLVER GLAQWVDSYY 900
TSL 903 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome. 
Interpro
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR002999; Tudor. 
Pfam
 PF00013; KH_1
 PF00567; TUDOR 
SMART
 SM00322; KH
 SM00333; TUDOR 
PROSITE
 PS50084; KH_TYPE_1
 PS50304; TUDOR 
PRINTS