UniProt Accession

 DHDDS_HUMAN; Q86SQ9; B7Z4B9; B7ZB20; D3DPK7; D3DPK8; D3DPK9; E9KL43; Q5T0A4; Q8NE90; Q9BTG5; Q9BTK3; Q9H905 

Genbank Protein ID

 AB090852; GU727641; AK023164; AK297134; AK316485; AL513365; CH471059; CH471059; CH471059; CH471059; CH471059; CH471059; BC003643; BC004117; BC034152 

Genbank Nucleotide ID

 BAC57588.1; ADU87642.1; BAB14439.1; BAH12505.1; BAH14856.1; CAI21495.1; EAX07806.1; EAX07808.1; EAX07809.1; EAX07810.1; EAX07811.1; EAX07812.1; AAH03643.1; AAH04117.1; AAH34152.1 

Protein Name

 Dehydrodolichyl diphosphate synthase 

Protein Synonyms/Alias

 Dedol-PP synthase; Cis-isoprenyltransferase; CIT; Cis-IPTase; Epididymis tissue protein Li 189m 

Gene Name

 DHDDS 

Gene Synonyms/Alias

 HDS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	IENFKRSKSEVDGLM	ubiquitination	[1]
320	FLQALELKRADWLAR	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome; Retinitis pigmentosa; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
 GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001441; UPP_synth-like.
 IPR018520; UPP_synth-like_CS. 

Pfam

 PF01255; Prenyltransf 

SMART

  

PROSITE

 PS01066; UPP_SYNTHASE 

PRINTS