| Tag | Content |
|---|
| CPLM ID | CPLM-016491 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SUN domain-containing protein 2 |
Protein Synonyms/Alias | Protein unc-84 homolog B; Sad1/unc-84 protein-like 2 |
Gene Name | Sun2 |
Gene Synonyms/Alias | Unc84b |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 547 | EQVHRIVKQALQRYS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5. |
Sequence Annotation | DOMAIN 569 730 SUN.
REGION 1 128 LMNA-binding.
MOD_RES 12 12 Phosphoserine (By similarity).
MOD_RES 39 39 Phosphoserine.
MOD_RES 55 55 Phosphoserine (By similarity).
CARBOHYD 650 650 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Endosome; Glycoprotein; Membrane; Nucleus; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 731 AA |
Protein Sequence | MSRRSQRLTR YSQDDNDGGS SSSGASSVAG SQGTVFKDSP LRTLKRKSSN MKHLSPAPQL 60
GPSSDSHTSY YSESVVRESY IGSPRAVSLA RSALLDDHLH SEPYWSGDLR GRRRRGTGGS 120
ESSKANGLTA ESKASEDFFG SSSGYSSEDD LAGYTDSDQH SSGSRLRSAA SRAGSFVWTL 180
VTFPGRLFGL LYWWIGTTWY RLTTAASLLD VFVLTRSRHF SLNLKSFLWF LLLLLLLTGL 240
TYGAWHFYPL GLQTLQPAVV SWWAAKESRK QPEVWESRDA SQHFQAEQRV LSRVHSLERR 300
LEALAADFSS NWQKEAIRLE RLELRQGAAG HGGGSSLSHE DALSLLEGLV SRREATLKED 360
LRRDTVAHIQ EELATLRAEH HQDSEDLFKK IVQASQESEA RVQQLKTEWK SMTQEAFQES 420
SVKELGRLEA QLASLRQELA ALTLKQNSVA DEVGLLPQKI QAARADVESQ FPDWIRQFLL 480
GDRGARSGLL QRDEMHAQLQ ELENKILTKM AEMQGKSARE AAASLGQILQ KEGIVGVTEE 540
QVHRIVKQAL QRYSEDRIGM VDYALESGGA SVISTRCSET YETKTALLSL FGIPLWYHSQ 600
SPRVILQPDV HPGNCWAFQG PQGFAVVRLS ARIRPTAVTL EHVPKALSPN STISSAPKDF 660
AIFGFDEDLQ QEGTLLGTFA YDQDGEPIQT FYFQASKMAT YQVVELRILT NWGHPEYTCI 720
YRFRVHGEPA H 731 |
Gene Ontology | GO:0000794; C:condensed nuclear chromosome; IDA:MGI. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0000784; C:nuclear chromosome, telomeric region; IDA:MGI. GO:0005637; C:nuclear inner membrane; IDA:UniProtKB. GO:0051642; P:centrosome localization; IMP:UniProtKB. GO:0031022; P:nuclear migration along microfilament; IMP:UniProtKB. GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB. |
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Pfam | |
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PROSITE | |
PRINTS | |