UniProt Accession

 STK16_HUMAN; O75716; A8K9H9; Q5U0F8; Q96KI2; Q9BUH4; Q9UEN3; Q9UP78 

Genbank Protein ID

 AJ005791; AF060798; AB020739; AJ010872; AF203910; BT019585; AK292694; CR407675; BC002618; BC053998 

Genbank Nucleotide ID

 CAA06700.1; AAC28337.1; BAB16311.1; CAA09387.1; AAG23728.1; AAV38392.1; BAF85383.1; CAG28603.1; AAH02618.1; AAH53998.1 

Protein Name

 Serine/threonine-protein kinase 16 

Protein Synonyms/Alias

 Myristoylated and palmitoylated serine/threonine-protein kinase; MPSK; Protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; Tyrosine-protein kinase STK16; hPSK 

Gene Name

 STK16 

Gene Synonyms/Alias

 MPSK1; PKL12; TSF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
102	WLLLPFFKRGTLWNE	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. 

Sequence Annotation

 DOMAIN 20 293 Protein kinase.
 NP_BIND 26 34 ATP (By similarity).
 REGION 166 202 Activation loop.
 ACT_SITE 148 148 Proton acceptor (By similarity).
 BINDING 49 49 ATP (By similarity).
 MOD_RES 185 185 Phosphothreonine; by autocatalysis.
 MOD_RES 197 197 Phosphoserine; by autocatalysis.
 MOD_RES 198 198 Phosphotyrosine; by autocatalysis.
 LIPID 2 2 N-myristoyl glycine.
 LIPID 6 6 S-palmitoyl cysteine (Probable).
 LIPID 8 8 S-palmitoyl cysteine (Probable).  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 305 AA 

Protein Sequence

Gene Ontology

 GO:0005798; C:Golgi-associated vesicle; IEA:Compara.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS