UniProt Accession

 GSTA1_HUMAN; P08263; Q14750; Q5GHF8; Q5SZC1 

Genbank Protein ID

 M15872; M21758; M25627; M14777; S76235; S76221; S76223; S76225; S76228; S76232; S49975; AY532928; CR407656; AL590363; CH471081; BC053578; BC110891 

Genbank Nucleotide ID

 AAA70226.1; AAA52615.1; AAA36174.1; AAA52618.1; AAB20973.1; AAB20973.1; AAB20973.1; AAB20973.1; AAB20973.1; AAB20973.1; AAB24012.1; AAT06769.1; CAG28584.1; CAI13812.1; EAX04385.1; AAH53578.1; AAI10892.1 

Protein Name

 Glutathione S-transferase A1 

Protein Synonyms/Alias

 GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1; Glutathione S-transferase A1, N-terminally processed 

Gene Name

 GSTA1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
84	SKYNLYGKDIKERAL	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 3 83 GST N-terminal.
 DOMAIN 85 207 GST C-terminal.
 REGION 54 55 Glutathione binding.
 REGION 67 68 Glutathione binding.
 BINDING 9 9 Glutathione.
 BINDING 45 45 Glutathione.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004364; F:glutathione transferase activity; IDA:UniProtKB.
 GO:0006749; P:glutathione metabolic process; IDA:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR003080; GST_alpha.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01266; GSTRNSFRASEA.