UniProt Accession

 D3ZXP3_RAT; D3ZXP3 

Genbank Protein ID

 AABR06054540; CH473975 

Genbank Nucleotide ID

 EDL95294.1 

Protein Name

 Histone H2A 

Protein Synonyms/Alias

  

Gene Name

 H2afx 

Gene Synonyms/Alias

 rCG_57928 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKTGGKARA	acetylation	[1]
10	GRGKTGGKARAKAKS	acetylation	[1]
120	QAVLLPKKTSATVGP	ubiquitination	[2]
134	PKAPAGGKKASQASQ	acetylation	[1]
135	KAPAGGKKASQASQE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

  

Sequence Annotation

  

Keyword

 Chromosome; Complete proteome; DNA-binding; Nucleosome core; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 143 AA 

Protein Sequence

Gene Ontology

 GO:0000781; C:chromosome, telomeric region; IEA:Compara.
 GO:0000794; C:condensed nuclear chromosome; IEA:Compara.
 GO:0001673; C:male germ cell nucleus; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005657; C:replication fork; IEA:Compara.
 GO:0001741; C:XY body; IEA:Compara.
 GO:0003684; F:damaged DNA binding; IEA:Compara.
 GO:0000077; P:DNA damage checkpoint; IEA:Compara.
 GO:0000724; P:double-strand break repair via homologous recombination; IEA:Compara.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.