CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030808
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 SUMO-protein ligase PIAS2 
Protein Synonyms/Alias
 cDNA FLJ57366, highly similar to Protein inhibitor of activated STAT2 
Gene Name
 PIAS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60SLMCPLGKMRLTIPCubiquitination[1]
153VSSQPCTKIESSSVLubiquitination[1]
162ESSSVLSKPCSVTVAubiquitination[1]
174TVASEASKKKVDVIDubiquitination[1]
175VASEASKKKVDVIDLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MSVYLVRQLT SAMLLQRLKM KGIRNPDHSR ALIKEKLTAD PDSEIATTSL RVSLMCPLGK 60
MRLTIPCRAV TCTHLQCFDA ALYLQMNEKK PTWICPVCDK KAAYESLILD GLFMEILNDC 120
SDVDEIKFQE DGSWCPMRPK KEAMKVSSQP CTKIESSSVL SKPCSVTVAS EASKKKVDVI 180
DLTIESSSDE EEDPPAKRKC IFMSETQSSP TKGVLMYQPS SVRVPSVTSV DPAAIPPSLT 240
DYSVPFHHTP ISSMSSDLPG EQRRNDINNE LKLGTSSDTV QQ 282 
Gene Ontology
 GO:0019789; F:SUMO ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR027228; PIAS2.
 IPR004181; Znf_MIZ. 
Pfam
 PF02891; zf-MIZ 
SMART
  
PROSITE
 PS51044; ZF_SP_RING 
PRINTS