CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016768
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial inner membrane protein 
Protein Synonyms/Alias
 Mitofilin 
Gene Name
 Immt 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
210ARLAQQEKQEQVEMEacetylation[1]
505KVQEQELKYEFEQGLacetylation[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647] 
Functional Description
  
Sequence Annotation
 MOD_RES 210 210 N6-acetyllysine (By similarity).
 MOD_RES 221 221 N6-acetyllysine (By similarity).
 MOD_RES 450 450 N6-acetyllysine (By similarity).
 MOD_RES 505 505 N6-acetyllysine.
 MOD_RES 506 506 Phosphotyrosine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 757 AA 
Protein Sequence
MLRACQLSGV TVAAQSCLCG KFVLRPLRPC RRYSTSSSSG LTAGKIAGAG LLFVGGGIGG 60
TILYAKWDSH FRESVEKTIP YSDKLFGMVL GSAPYTVPLP KKPVQSGPLK ISSVSEVMKD 120
SKLPVAQSQK TKGDTPASAA STGAAQIISA AGDTLSVPAP AVQHEDTIKT ECPNTNEGKS 180
TSETTEEAFS SSVRERPPEE VAARLAQQEK QEQVEMESLA KSLEDALNRT SSVTLQTITA 240
QNAAVQAVKA HSNILKTAMD NSEIAGEKKS AQWRTVEGAL KERRKAVDEA ADALLKAKEE 300
LEKMKTIIED AKKREIAGAT PHITAAEGRL HNMIVDLDNV VKKVQAAQSE AKVVSQYHEL 360
VVQARDDFRK ELDSITPDIT PGWKGMSISD LAGKLSTDDL NSLIAHAHRR IDQLNRELAQ 420
QKATEKQHIE LALEKHKLEE KRTFDSAVAK ALEHHRSEIQ AEQDRKVEEV RDAMENEMRT 480
QLRRQAAAHT DHLRDVLKVQ EQELKYEFEQ GLSEKLSEQE LEFRRRSQEQ MDSFTLDINT 540
AYARLRGIEQ AVQSHAVAEE EARKAHQLWL SVEALKYSMK TSSAEMPTIP LGSAVEAIRV 600
NCSDNEFTQA LTAAIPPESL TRGVYSEETL RARFYAVQKL ARRVAMIDET RNSLYQYFLS 660
YLQSLLLFPP KQLKPPAELY PEDINTFKLL SYASYCIEHG DLELAAKFVN QLKGESRRVA 720
QDWLKEARMT LETKQIVEIL TAYASAVGIG TTQVQQE 757 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
 GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:MGI.
 GO:0009409; P:response to cold; IEA:Compara. 
Interpro
 IPR019133; Mt-IM_prot_Mitofilin. 
Pfam
 PF09731; Mitofilin 
SMART
  
PROSITE
  
PRINTS