CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001343
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Craniofacial development protein 1 
Protein Synonyms/Alias
 27 kDa craniofacial protein; Bucentaur; Protein Cp27 
Gene Name
 Cfdp1 
Gene Synonyms/Alias
 Bcnt; Cfdp; Cp27 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
142TEEISSNKPLVKADEacetylation[1]
163SEKVKITKVFDFAGEacetylation[2, 3]
176GEEVRVTKEVDAASKacetylation[2]
186DAASKEAKSFLKQTEacetylation[4]
226GMSSLLGKIGAKKQKubiquitination[5]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role during embryogenesis. May modulate tooth organogenesis since alterations of this protein function affect tooth organs size as well as individual cell fate and survival. In embryonic cells, blockage of the function results in increased number of apoptotic cells, reduced proliferation, alterations in cell shape and fibronection matrix synthesis. 
Sequence Annotation
 DOMAIN 214 295 BCNT-C.
 REGION 174 213 Hydrophilic.
 MOD_RES 112 112 Phosphoserine (By similarity).
 MOD_RES 246 246 Phosphoserine.  
Keyword
 Complete proteome; Developmental protein; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 295 AA 
Protein Sequence
MEEFDSEDFS TSDEDEDYLP SGGEYSEDDV NELVKEDEVD GEEQAEKTKG KRRKAQGIPA 60
RKRKQSGLLL EEEEDGKEDS GGSSSEEDEE EQEGGLGSEN ARKKKEDELW ASFLNDVGPK 120
SKAAPGSQTK VAEETEEISS NKPLVKADEL DKPRESEKVK ITKVFDFAGE EVRVTKEVDA 180
ASKEAKSFLK QTEREKPQAL VTSPATPLPA GSGIKRASGM SSLLGKIGAK KQKMSTLEKS 240
KLDWESFKEE EGIGEELAIH NRGKEGYIER KAFLDRVDHR QFEIERDLRL SKMKP 295 
Gene Ontology
 GO:0005604; C:basement membrane; TAS:MGI.
 GO:0007155; P:cell adhesion; IDA:MGI.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0042127; P:regulation of cell proliferation; IDA:MGI.
 GO:0008360; P:regulation of cell shape; IDA:MGI. 
Interpro
 IPR011421; BCNT-C.
 IPR027124; Swc5/CFDP. 
Pfam
 PF07572; BCNT 
SMART
  
PROSITE
 PS51279; BCNT_C 
PRINTS