CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein PIN4 
Protein Synonyms/Alias
 Psi inducibility protein 4 
Gene Name
 PIN4 
Gene Synonyms/Alias
 MDT1; YBL051C; YBL0506; YBL0516 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
44ETRDAIDKENGVQTEubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in normal G2/M phase transition of the mitotic cell cycle. In association with RAD53, also involved in checkpoint control in response to DNA damage. 
Sequence Annotation
 DOMAIN 85 163 RRM.
 MOD_RES 56 56 Phosphoserine.
 MOD_RES 189 189 Phosphoserine.
 MOD_RES 191 191 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 197 197 Phosphoserine.
 MOD_RES 305 305 Phosphothreonine; by ATR.
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 466 466 Phosphoserine.
 MOD_RES 541 541 Phosphoserine.
 MOD_RES 636 636 Phosphoserine.
 MOD_RES 638 638 Phosphoserine.
 MOD_RES 640 640 Phosphoserine.
 MOD_RES 653 653 Phosphoserine.
 MOD_RES 655 655 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 668 AA 
Protein Sequence
METSSFENAP PAAINDAQDN NINTETNDQE TNQQSIETRD AIDKENGVQT ETGENSAKNA 60
EQNVSSTNLN NAPTNGALDD DVIPNAIVIK NIPFAIKKEQ LLDIIEEMDL PLPYAFNYHF 120
DNGIFRGLAF ANFTTPEETT QVITSLNGKE ISGRKLKVEY KKMLPQAERE RIEREKREKR 180
GQLEEQHRSS SNLSLDSLSK MSGSGNNNTS NNQLFSTLMN GINANSMMNS PMNNTINNNS 240
SNNNNSGNII LNQPSLSAQH TSSSLYQTNV NNQAQMSTER FYAPLPSTST LPLPPQQLDF 300
NDPDTLEIYS QLLLFKDREK YYYELAYPMG ISASHKRIIN VLCSYLGLVE VYDPRFIIIR 360
RKILDHANLQ SHLQQQGQMT SAHPLQPNST GGSMNRSQSY TSLLQAHAAA AANSISNQAV 420
NNSSNSNTIN SNNGNGNNVI INNNSASSTP KISSQGQFSM QPTLTSPKMN IHHSSQYNSA 480
DQPQQPQPQT QQNVQSAAQQ QQSFLRQQAT LTPSSRIPSG YSANHYQINS VNPLLRNSQI 540
SPPNSQIPIN SQTLSQAQPP AQSQTQQRVP VAYQNASLSS QQLYNLNGPS SANSQSQLLP 600
QHTNGSVHSN FSYQSYHDES MLSAHNLNSA DLIYKSLSHS GLDDGLEQGL NRSLSGLDLQ 660
NQNKKNLW 668 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000077; P:DNA damage checkpoint; IPI:SGD.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:SGD. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
  
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS