UniProt Accession

 RAB5B_MOUSE; P61021; P35239; P35277 

Genbank Protein ID

 X84239; AK081251; M79311 

Genbank Nucleotide ID

 CAA59016.1; BAC38176.1; AAK14835.1 

Protein Name

 Ras-related protein Rab-5B 

Protein Synonyms/Alias

  

Gene Name

 Rab5b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
116	ARAKTWVKELQRQAS	ubiquitination	[1]
134	VIALAGNKADLANKR	ubiquitination	[1]
140	NKADLANKRMVEYEE	ubiquitination	[1]
183	AIAKKLPKSEPQNLG	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Protein transport. Probably involved in vesicular traffic (By similarity). 

Sequence Annotation

 NP_BIND 27 35 GTP (By similarity).
 NP_BIND 75 79 GTP (By similarity).
 NP_BIND 133 136 GTP (By similarity).
 NP_BIND 163 165 GTP (By similarity).
 MOTIF 49 57 Effector region (Potential).
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 LIPID 212 212 S-geranylgeranyl cysteine (By
 LIPID 213 213 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Cell membrane; Complete proteome; Direct protein sequencing; Endosome; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030139; C:endocytic vesicle; IDA:MGI.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:MGI.
 GO:0007032; P:endosome organization; IDA:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0030100; P:regulation of endocytosis; IDA:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.