UniProt Accession

 PYRB_ECOLI; P0A786; P00479; Q2M662; Q47555; Q47557 

Genbank Protein ID

 J01670; K01472; U14003; U00096; AP009048; M10743; M60508 

Genbank Nucleotide ID

 AAA24474.1; AAA24476.1; AAA97142.1; AAC77202.1; BAE78244.1; AAA24479.1; AAA24481.1 

Protein Name

 Aspartate carbamoyltransferase catalytic chain 

Protein Synonyms/Alias

 Aspartate transcarbamylase; ATCase 

Gene Name

 pyrB 

Gene Synonyms/Alias

 b4245; JW4204 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
8	MANPLYQKHIISIND	acetylation	[1]
30	LVLATAAKLKANPQP	acetylation	[1]
32	LATAAKLKANPQPEL	acetylation	[1]
41	NPQPELLKHKVIASC	acetylation	[1]
43	QPELLKHKVIASCFF	acetylation	[1]
84	SANTSLGKKGETLAD	acetylation	[1]
165	VAMVGDLKYGRTVHS	acetylation	[1, 2]
179	SLTQALAKFDGNRFY	acetylation	[1, 2]
233	LYMTRVQKERLDPSE	acetylation	[1]
245	PSEYANVKAQFVLRA	acetylation	[1]
263	HNAKANMKVLHPLPR	acetylation	[1]
280	EIATDVDKTPHAWYF	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508] 

Functional Description

  

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Pyrimidine biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 311 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016597; F:amino acid binding; IEA:InterPro.
 GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
 GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. 

Interpro

 IPR006132; Asp/Orn_carbamoyltranf_P-bd.
 IPR006130; Asp/Orn_carbamoylTrfase.
 IPR002082; Asp_carbamoyltransf.
 IPR006131; Asp_carbamoyltransf_Asp/Orn-bd. 

Pfam

 PF00185; OTCace
 PF02729; OTCace_N 

SMART

  

PROSITE

 PS00097; CARBAMOYLTRANSFERASE 

PRINTS

 PR00100; AOTCASE.
 PR00101; ATCASE.