CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029223
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 splice variant 2 
Protein Synonyms/Alias
 Protein Pfkfb3 
Gene Name
 Pfkfb3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
292FVEEQNLKDLRVWTSubiquitination[1]
302RVWTSQLKSTIQTAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 555 AA 
Protein Sequence
MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN 60
WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMRVRK QCALAALRDV KSYLTKEGGQ 120
IAVFDATNTT RERRHMILNF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS 180
AEAMDDFMKR INCYEASYQP LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM 240
NIHVQPRTIY LCRHGENEYN LQGKIGGDSG LSSRGKKFAN ALSKFVEEQN LKDLRVWTSQ 300
LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG 360
ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL 420
TPVAYGCRVE SIYLNVESVS THRERSEAVK IQHFASVVRP SSYTELDFQS VESAKQDAKK 480
GPNPLMRRNS VTPLASPEPT KKPRINSFEE RVASTSAALP SCLPPEVPTQ LPGQPLLGKA 540
CLRSVCHIFS KFSPY 555 
Gene Ontology
 GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
 GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
 GO:0006000; P:fructose metabolic process; IEA:InterPro. 
Interpro
 IPR003094; 6Pfruct_kin.
 IPR013079; 6Phosfructo_kin.
 IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
 IPR013078; His_Pase_superF_clade-1.
 IPR027417; P-loop_NTPase.
 IPR001345; PG/BPGM_mutase_AS. 
Pfam
 PF01591; 6PF2K
 PF00300; His_Phos_1 
SMART
 SM00855; PGAM 
PROSITE
 PS00175; PG_MUTASE 
PRINTS
 PR00991; 6PFRUCTKNASE.