UniProt Accession

 FANCC_HUMAN; Q00597; B1ALR8 

Genbank Protein ID

 X66894; X66893; L02664; L02651; L02652; L02653; L02654; L02655; L02656; L02657; L02658; L02659; L02660; L02661; L02662; L02663; AY220878; AL157384; AL354893; AL354893; AL157384; CH471174; BC015748 

Genbank Nucleotide ID

 CAA47348.1; CAA47347.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAA53104.1; AAO26042.1; CAH70886.1; CAH70886.1; CAI41329.1; CAI41329.1; EAW92626.1; AAH15748.1 

Protein Name

 Fanconi anemia group C protein 

Protein Synonyms/Alias

 Protein FACC 

Gene Name

 FANCC 

Gene Synonyms/Alias

 FAC; FACC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
230	VNEAILLKKISLPMS	ubiquitination	[1]
277	RRIECFIKDSSLPQA	ubiquitination	[1, 2, 3]
447	AQTMVQVKAVLGHLL	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Disease mutation; DNA damage; DNA repair; Fanconi anemia; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0043240; C:Fanconi anaemia nuclear complex; IDA:UniProtKB.
 GO:0006281; P:DNA repair; TAS:Reactome.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0002262; P:myeloid cell homeostasis; IEA:Compara.
 GO:0006289; P:nucleotide-excision repair; IEA:Compara.
 GO:0006461; P:protein complex assembly; TAS:ProtInc.
 GO:0019430; P:removal of superoxide radicals; IEA:Compara. 

Interpro

 IPR000686; Fanconi. 

Pfam

 PF02106; Fanconi_C 

SMART

  

PROSITE

  

PRINTS

 PR00494; FANCONICGENE.