CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014957
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pannexin-2 
Protein Synonyms/Alias
  
Gene Name
 Panx2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
183IEKQIQSKGPGITERubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Structural component of the gap junctions and the hemichannels. 
Sequence Annotation
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Gap junction; Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MHHLLEQSAD MATALLAGEK LRELILPGSQ DDKAGALAAL LLQLKLELPF DRVVTIGTVL 60
VPILLVTLVF TKNFAEEPIY CYTPHNFTRD QALYARGYCW TELRDALPGV DASLWPSLFE 120
HKFLPYALLA FAAIMYVPAL GWEFLASTRL TSELNFLLQE IDNCYHRAAE GRAPKIEKQI 180
QSKGPGITER EKREIIENAE KEKSPEQNLF EKYLERRGRS NFLAKLYLAR HVLILLLSVV 240
PISYLCTYYA TQKQNEFTCA LGASPDGPVG SAGPTVRVSC KLPSVQLQRI IAGVDIVLLC 300
FMNLIILVNL IHLFIFRKSN FIFDKLNKVG IKTRRQWRRS QFCDINILAM FCNENRDHIK 360
SLNRLDFITN ESDLMYDNVV RQLLAALAQS NHDTTPTVRD SGIQTVDPSI NPAEPDGSAE 420
PPVVKRPRKK MKWIPTSNPL PQPFKEQLAI MRVENSKTEK PKPVRRKTAT DTLIAPLLDA 480
GARAAHHYKG SGGDSGPSSA PPAASEKKHT RHFSLDVHPY ILGTKKAKTE AVPPALPASR 540
SQEGGFLSQT EECGLGLAAA PTKDAPLPEK EIPYPTEPAL PGLPSGGSFH VCSPPAAPAA 600
ASLSPGSLGK ADPLTILSRN ATHPLLHIST LYEAREEEEG GPCAPSDMGD LLSIPPPQQI 660
LIATFEEPRT VVSTVEF 677 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IC:MGI.
 GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
 GO:0007267; P:cell-cell signaling; IEA:Compara.
 GO:0006811; P:ion transport; IEA:UniProtKB-KW.
 GO:0034214; P:protein hexamerization; ISS:UniProtKB.
 GO:0002931; P:response to ischemia; IGI:MGI. 
Interpro
 IPR000990; Innexin. 
Pfam
 PF00876; Innexin 
SMART
  
PROSITE
 PS51013; PANNEXIN 
PRINTS