UniProt Accession

 CAV1_RAT; P41350; Q8VIK8; Q8VIK9 

Genbank Protein ID

 Z46614; AF439778; AF439779 

Genbank Nucleotide ID

 CAA86587.1; AAL33579.1; AAL33580.1 

Protein Name

 Caveolin-1 

Protein Synonyms/Alias

  

Gene Name

 Cav1 

Gene Synonyms/Alias

 Cav 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
5	***MSGGKYVDSEGH	acetylation	[1]
5	***MSGGKYVDSEGH	ubiquitination	[2]
26	REQGNIYKPNNKAMA	acetylation	[1]
26	REQGNIYKPNNKAMA	ubiquitination	[2]
30	NIYKPNNKAMADEVN	acetylation	[1]
39	MADEVNEKQVYDAHT	acetylation	[1]
47	QVYDAHTKEIDLVNR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 5 5 N6-acetyllysine (By similarity).
 MOD_RES 6 6 Phosphotyrosine (By similarity).
 MOD_RES 14 14 Phosphotyrosine; by ABL1 (By similarity).
 MOD_RES 25 25 Phosphotyrosine (By similarity).
 MOD_RES 42 42 Phosphotyrosine (By similarity).
 LIPID 133 133 S-palmitoyl cysteine (By similarity).
 LIPID 143 143 S-palmitoyl cysteine (By similarity).
 LIPID 156 156 S-palmitoyl cysteine (By similarity).  

Keyword

 Acetylation; Alternative initiation; Cell membrane; Complete proteome; Golgi apparatus; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0009925; C:basal plasma membrane; IDA:RGD.
 GO:0005901; C:caveola; IDA:UniProtKB.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0031410; C:cytoplasmic vesicle; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005783; C:endoplasmic reticulum; ISS:HGNC.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0005925; C:focal adhesion; IDA:RGD.
 GO:0000139; C:Golgi membrane; ISS:HGNC.
 GO:0016021; C:integral to membrane; TAS:RGD.
 GO:0005811; C:lipid particle; IDA:RGD.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005778; C:peroxisomal membrane; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0005198; F:structural molecule activity; ISS:HGNC.
 GO:0019905; F:syntaxin binding; IMP:RGD.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:RGD.
 GO:0071260; P:cellular response to mechanical stimulus; IDA:RGD.
 GO:0033344; P:cholesterol efflux; IMP:RGD.
 GO:0032507; P:maintenance of protein location in cell; IMP:BHF-UCL.
 GO:0046785; P:microtubule polymerization; IMP:RGD.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:2001258; P:negative regulation of cation channel activity; IDA:RGD.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:RGD.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:RGD.
 GO:0010656; P:negative regulation of muscle cell apoptotic process; IMP:RGD.
 GO:0045665; P:negative regulation of neuron differentiation; IMP:RGD.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0045807; P:positive regulation of endocytosis; IMP:RGD.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IMP:RGD.
 GO:0031116; P:positive regulation of microtubule polymerization; IMP:RGD.
 GO:0009967; P:positive regulation of signal transduction; IMP:RGD.
 GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0010332; P:response to gamma radiation; IEP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0031295; P:T cell costimulation; ISS:UniProtKB.
 GO:0045056; P:transcytosis; TAS:RGD. 

Interpro

 IPR001612; Caveolin.
 IPR015504; Caveolin_1.
 IPR018361; Caveolin_CS. 

Pfam

 PF01146; Caveolin 

SMART

  

PROSITE

 PS01210; CAVEOLIN 

PRINTS