UniProt Accession

 MYL9_HUMAN; P24844; E1P5T6; Q9BQL9; Q9BUF9; Q9H136 

Genbank Protein ID

 J02854; AF176043; D82057; AL050318; AL050318; CH471077; CH471077; CH471077; CH471077; CH471077; BC002648 

Genbank Nucleotide ID

 AAA59852.1; AAQ13654.1; BAB88917.1; CAB75369.1; CAC34440.2; EAW76129.1; EAW76131.1; EAW76132.1; EAW76133.1; EAW76134.1; AAH02648.1 

Protein Name

 Myosin regulatory light polypeptide 9 

Protein Synonyms/Alias

 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1 

Gene Name

 MYL9 

Gene Synonyms/Alias

 MLC2; MRLC1; MYRL2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	NRDGFIDKEDLHDML	ubiquitination	[1]
150	YREAPIDKKGNFNYV	ubiquitination	[1]
151	REAPIDKKGNFNYVE	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. 

Sequence Annotation

 DOMAIN 29 64 EF-hand 1.
 DOMAIN 98 133 EF-hand 2.
 DOMAIN 134 169 EF-hand 3.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 19 19 Phosphothreonine; by MLCK, CIT and ROCK2.
 MOD_RES 20 20 Phosphoserine; by CDC42BP, CIT, MLCK,
 MOD_RES 29 29 Phosphoserine (By similarity).
 MOD_RES 135 135 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Calcium; Complete proteome; Metal-binding; Motor protein; Muscle protein; Myosin; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 172 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005859; C:muscle myosin complex; TAS:ProtInc.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0006936; P:muscle contraction; TAS:Reactome.
 GO:0006937; P:regulation of muscle contraction; TAS:ProtInc. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS