Tag | Content |
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CPLM ID | CPLM-015234 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein tyrosine phosphatase type IVA 2 |
Protein Synonyms/Alias | Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2 |
Gene Name | Ptp4a2 |
Gene Synonyms/Alias | Prl2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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29 | PTNATLNKFTEELKK | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). |
Sequence Annotation | DOMAIN 79 145 Tyrosine-protein phosphatase. REGION 102 107 Phosphate binding (By similarity). ACT_SITE 69 69 Proton donor (By similarity). ACT_SITE 101 101 Phosphocysteine intermediate (By BINDING 107 107 Substrate (By similarity). MOD_RES 164 164 Cysteine methyl ester (By similarity). LIPID 164 164 S-farnesyl cysteine (By similarity). DISULFID 46 101 By similarity. |
Keyword | Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Endosome; Hydrolase; Lipoprotein; Membrane; Methylation; Prenylation; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 167 AA |
Protein Sequence | MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY DKAPVEKEGI 60 HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH CVAGLGRAPV LVALALIECG 120 MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR PKMRLRFRDT NGHCCVQ 167 |
Gene Ontology | GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. |
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