CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024512
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 RNA polymerase II transcription factor SIII subunit A3-like-2 
Protein Synonyms/Alias
 Elongin-A3-like-2; EloA3-like-2; Transcription elongation factor B polypeptide 3C-like-2 
Gene Name
 TCEB3CL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21LQVRLATKTEPKKLEacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). 
Sequence Annotation
 DOMAIN 5 80 TFIIS N-terminal.
 REGION 308 467 Activation domain (By similarity).
 REGION 336 345 Interaction with elongin BC (By  
Keyword
 Complete proteome; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 546 AA 
Protein Sequence
MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR KTVKRLRKHQ 60
HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG EALQEREKAW GFPENATAPR 120
SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE PRAERKRPRM APADSGPHRD PPTRTAPLPM 180
PEGPEPAVPG EQPGRGHAHA AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP 240
VQESQSERLQ AAVADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL 300
SAPTLQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD ALGDVEGVPY 360
SALEPVLEGW TPDQPYRTEK DNAALARETD ELWRIHCLQD FKEEKPQEHE SWRELYLRLR 420
DAREQRLRVV TTKIRSAREN KPSGRQTKMI CFNSVAKTPY DASRRQEKSA GAADPGNGEM 480
EPAPKPAGSS QAPSGLGDGD GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK 540
GRFSRR 546 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR010684; RNA_pol_II_trans_fac_SIII_A.
 IPR017923; TFIIS_N. 
Pfam
 PF06881; Elongin_A
 PF08711; Med26 
SMART
  
PROSITE
 PS51319; TFIIS_N 
PRINTS