CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024786
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mediator of RNA polymerase II transcription subunit 13 
Protein Synonyms/Alias
 Protein GRAND CENTRAL; Protein MACCHI-BOU 2 
Gene Name
 MED13 
Gene Synonyms/Alias
 GCT; MAB2; MED13_1; At1g55325; F7A10.14 
Created Date
 July 27, 2013 
Organism
 Arabidopsis thaliana (Mouse-ear cress) 
NCBI Taxa ID
 3702 
Lysine Modification
Position
Peptide
Type
References
220YRLPAFRKCLGLAKSubiquitination[1]
226RKCLGLAKSEDNRLCubiquitination[1]
Reference
 [1] Multidimensional protein identification technology (MudPIT) analysis of ubiquitinated proteins in plants.
 Maor R, Jones A, Nühse TS, Studholme DJ, Peck SC, Shirasu K.
 Mol Cell Proteomics. 2007 Apr;6(4):601-10. [PMID: 17272265] 
Functional Description
 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts closely together with MAB12. Involved in the regulation of embryo patterning and cotyledon organogenesis. May act through transient repression of specific genes such as the ones responsive to auxin. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; Growth regulation; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1921 AA 
Protein Sequence
MWTNVFRIGG LHNVSWFQFL PSETELNPGF DRSSRAEQNE VATYLVLSSH LRLQKEGFLT 60
TWTNSFVGPW DPSQGLYNPD EKIKLWLFLP GRHSSISDKA QAAVSKLRVV ASGIWVAPGD 120
SEEISVAFSQ SLRNCIERAL SGISYMRFGD VFSKFSPQSE EYLRRGQPTV EFIFAATEEA 180
VFVHVIISAK NVRTLSSGDA ERMLRSSLKN SSYRLPAFRK CLGLAKSEDN RLCYINTSHR 240
PMLFPPVIVS PHGMRGSLTG FCPNDLVKQV YFSSGNLKTS TGYVGLPSHI GRGSRLINGN 300
HCYVEVTLGC CQNRNDNTSQ ANSTFAVNLP HNQCPEPSVG SKDHRKGQSD LSSVCEKKFI 360
YPAEAVLVPI LQSAFAKFSL KRAGDFDCLG ASENKSDGFY EKNGYNSSGS SRNSSISSTS 420
SASSGSGWRM TSRTGDLDAD ADSLTCRQSG LTCNDDRLKM GSKRPRTGMA ESFGQVGIEN 480
DQIGWDWDAD DDDDDREVGM DIKALLSEFG DFGDFFENDA LPFGEPPGTA ESHVLVFPPD 540
SADVGSSPVD MMDVSDQIVL PVGFSSFESF NPVPPIIDEC LIKSQEVLHS SITSVPSNQM 600
SISSTGEFDH LLKAEAMMTF APEYGAVEAP MSEISSTFFK SPYLPKSHKV ESSNSRTSNY 660
VYGATPPTTD SDGAGDMILF GSKSCIGNNA GRTLYHSREH YTQVEGRKGR HDKLPTVISD 720
NSSTKEGVSQ SIHSKHSAAN AVKVVQGKKT DGISAVVSTL LSSKTLLATD VGSVMFQAFM 780
CRMRHIITSS KHSSPVSLTR LSGNFFLNQL SNEPSTLTDN ISARNEIYKK DIPTRIAGDF 840
DGGMLDSHMS APVGVWRTVS VPKTAKPASS PNIEAGSSLP HSSFSEDSLL SYGQRQPLQD 900
LLDGIALLVQ QATSFVDLAL DSDCGDGPYG WLALEELWRR ELSCGPSAGH AGCGGTLASC 960
HSLDIAGVKL VDPLSAEVFP SSVITLLQSD IKTALKSAFG QSDGPLSVTD WCKGRNQSGD 1020
GGSISEGFTA ESALSEVNGV NISDDFIIDK YFGKQAVSNA IDGGKGDETA QSQDIYSSEL 1080
LRPTLFVLPS PAILVGYQDD WLKISTNSLT HWEKAPFEPY ALPKSINYAV VCPDIDPLTC 1140
AATDFFQQLG TGESTSLSFV KEVMLKHDRN WLGTHLPQSL GNQMEKDVGR LSSSGFVLLD 1200
CPQSMKIESN NTSLLGSLSD YFLSLSNGWN VNSYLKSLSK ALKGLKLGSG LYTNQKEGSG 1260
SPCVVVYIVC PFPDPSAVLR TIVESSIALG SVIQSDRDRR SILNSQVARA FSSSTAVDEA 1320
SISHIPVLSG FSVPKLVLQV VSVDSIFRIT SPSFNELVIL KDTAFSVYNK ARRISRGMPN 1380
DAFFSSSLPS RSSSALTPMN SISGIWKDCG GSRMTGSTHP RDGEIDVSLR TSGWDTSTSW 1440
QIPRSGGLSC DPNRNGDFYL NDEIFYLFEP LFILSEPGSV ERGVSPTFTS LGSESSKPIP 1500
EDGGRGSGPG MNSMEGITSG SSSQGDVSQL EGKAIPSLHC CYGWTEDWRW LVSIWTDARV 1560
LQQGCQILQA CSSPDNGSFK PRDFVITRIG NFFELEYQEW QKAIYSAGGP EIKKWPIQLR 1620
RSAPSGIATN SNGSSLQQQD LSLIQERASS TSTLYSSHSK QSTFVKGSMG QSAGRKQIMG 1680
GQTISGTPRG LFQWVHSISF ASISLDHSLH FVLPAELVSA GGGQSSTGMS SVNYIEGFTP 1740
VKSLGSTAFS YMMIPSPNMR FLHPSPLQLP TCLTAESPPL AHLLHSKGYA IPLSTGFVVS 1800
KAVPSMRKDS RINVKEEWPS VLSVSLIDYY GGYDNAHDKI LQGIVKQGGG TKETRDFEVE 1860
SHLILESIAA ELHALSWMTV SPAYLDRRTA LPFHCDMVLR LRRLLHFADK EVSRIPDKTG 1920
V 1921 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS