CPLM-000833

Genbank Nucleotide ID

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Protein Synonyms/Alias

BRG1-associated factor 57; BAF57

Mus musculus (Mouse)

Position	Peptide	Type	References
92	KASNPDLKLWEIGKI	ubiquitination	[1]
146	YLAYINAKSRAEAAL	acetylation	[2]
189	YDDGFSMKHTATARF	ubiquitination	[1]
240	SLMVHQRKLEAELLQ	ubiquitination	[1]
271	DSFNNELKRLCGLKV	ubiquitination	[1]
328	EEEQVANKAEEKKDE	acetylation	[3]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]

Functional Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

DNA_BIND 66 134 HMG box.
MOD_RES 265 265 Phosphoserine (By similarity).

Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0071565; C:nBAF complex; IDA:UniProtKB.
GO:0071564; C:npBAF complex; IDA:UniProtKB.
GO:0016514; C:SWI/SNF complex; IDA:MGI.
GO:0017053; C:transcriptional repressor complex; IEA:Compara.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0008080; F:N-acetyltransferase activity; IEA:Compara.
GO:0006338; P:chromatin remodeling; IEA:Compara.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO:0006337; P:nucleosome disassembly; IEA:Compara.

IPR009071; HMG_box_dom.

PS00353; HMG_BOX_1
PS50118; HMG_BOX_2