CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029241
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beta-globin 
Protein Synonyms/Alias
 Hemoglobin subunit beta-1; Hemoglobin subunit beta-2 
Gene Name
 Hbb-b1 
Gene Synonyms/Alias
 Hbb-b2; Hbbt1; Hbbt2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
9VHLTDAEKAAVSGLWacetylation[1]
9VHLTDAEKAAVSGLWubiquitination[2]
18AVSGLWGKVNADEVGacetylation[1, 3]
18AVSGLWGKVNADEVGphosphoglycerylation[4]
18AVSGLWGKVNADEVGubiquitination[2]
60SAIMGNAKVKAHGKKacetylation[5]
60SAIMGNAKVKAHGKKsuccinylation[5]
60SAIMGNAKVKAHGKKubiquitination[2]
62IMGNAKVKAHGKKVIubiquitination[2]
67KVKAHGKKVITAFNDacetylation[1]
67KVKAHGKKVITAFNDubiquitination[2]
83LNHLDSLKGTFASLSphosphoglycerylation[4]
83LNHLDSLKGTFASLSubiquitination[2]
96LSELHCDKLHVDPENacetylation[1, 3, 6, 7, 8]
96LSELHCDKLHVDPENphosphoglycerylation[4]
96LSELHCDKLHVDPENubiquitination[2]
121VLGHHLGKDFTPAAQubiquitination[2]
133AAQAAFQKVVAGVAAubiquitination[2]
145VAAALAHKYH*****acetylation[3, 8, 9]
145VAAALAHKYH*****phosphoglycerylation[4]
145VAAALAHKYH*****ubiquitination[2]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [7] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [8] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [9] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 147 AA 
Protein Sequence
MVHLTDAEKA AVSGLWGKVN ADEVGGEALG RLLVVYPWTQ RYFDSFGDLS SASAIMGNAK 60
VKAHGKKVIT AFNDGLNHLD SLKGTFASLS ELHCDKLHVD PENFRLLGNM IVIVLGHHLG 120
KDFTPAAQAA FQKVVAGVAA ALAHKYH 147 
Gene Ontology
 GO:0005833; C:hemoglobin complex; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:InterPro.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. 
Interpro
 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002337; Haemoglobin_b. 
Pfam
 PF00042; Globin 
SMART
  
PROSITE
 PS01033; GLOBIN 
PRINTS
 PR00814; BETAHAEM.