| Tag | Content |
|---|
| CPLM ID | CPLM-003770 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal recognition particle receptor FtsY |
Protein Synonyms/Alias | SRP receptor |
Gene Name | ftsY |
Gene Synonyms/Alias | b3464; JW3429 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 24 | QKEQTPEKETEVQNE | acetylation | [1] | | 281 | EMGEILAKVDEPLNV | acetylation | [1] | | 372 | FDAIQAAKARNIDVL | acetylation | [1] | | 390 | TAGRLQNKSHLMEEL | acetylation | [1] | | 398 | SHLMEELKKIVRVMK | acetylation | [1] | | 399 | HLMEELKKIVRVMKK | acetylation | [1] | | 484 | IEDLRPFKADDFIEA | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. |
Sequence Annotation | NP_BIND 300 307 GTP (By similarity).
NP_BIND 382 386 GTP (By similarity).
NP_BIND 446 449 GTP (By similarity). |
Keyword | 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Membrane; Nucleotide-binding; Receptor; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 497 AA |
Protein Sequence | MAKEKKRGFF SWLGFGQKEQ TPEKETEVQN EQPVVEEIVQ AQEPVKASEQ AVEEQPQAHT 60
EAEAETFAAD VVEVTEQVAE SEKAQPEAEV VAQPEPVVEE TPEPVAIERE ELPLPEDVNA 120
EAVSPEEWQA EAETVEIVEA AEEEAAKEEI TDEELETALA AEAAEEAVMV VPPAEEEQPV 180
EEIAQEQEKP TKEGFFARLK RSLLKTKENL GSGFISLFRG KKIDDDLFEE LEEQLLIADV 240
GVETTRKIIT NLTEGASRKQ LRDAEALYGL LKEEMGEILA KVDEPLNVEG KAPFVILMVG 300
VNGVGKTTTI GKLARQFEQQ GKSVMLAAGD TFRAAAVEQL QVWGQRNNIP VIAQHTGADS 360
ASVIFDAIQA AKARNIDVLI ADTAGRLQNK SHLMEELKKI VRVMKKLDVE APHEVMLTID 420
ASTGQNAVSQ AKLFHEAVGL TGITLTKLDG TAKGGVIFSV ADQFGIPIRY IGVGERIEDL 480
RPFKADDFIE ALFARED 497 |
Gene Ontology | GO:0005829; C:cytosol; IDA:EcoCyc. GO:0031226; C:intrinsic to plasma membrane; IDA:EcoCyc. GO:0005525; F:GTP binding; IDA:EcoCyc. GO:0003924; F:GTPase activity; IDA:EcoCyc. GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IDA:EcoCyc. |
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PRINTS | |