CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006373
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UBX domain-containing protein 1 
Protein Synonyms/Alias
 Suppressor of high-copy PP1 protein 
Gene Name
 SHP1 
Gene Synonyms/Alias
 UBX1; YBL058W; YBL0509; YBL0515 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
66RQQEKALKQEAFSTNubiquitination[1]
90HVGGLCPKPGSSQGSubiquitination[1]
102QGSNEYLKRKGSTSPubiquitination[1]
113STSPEPTKGSSRSGSubiquitination[1]
170SDPNSLLKDLLEKARubiquitination[2]
175LLKDLLEKARRGGQMubiquitination[1]
241TREITFWKEGFQVADubiquitination[1, 2]
302SYKAPTRKLGGFSGQubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Direct or indirect positive regulator of GLC7 activity. 
Sequence Annotation
 DOMAIN 232 297 SEP.
 DOMAIN 344 421 UBX.
 MOD_RES 128 128 Phosphoserine.
 MOD_RES 210 210 Phosphoserine.
 MOD_RES 224 224 Phosphoserine.
 MOD_RES 315 315 Phosphoserine.
 MOD_RES 321 321 Phosphoserine.
 MOD_RES 322 322 Phosphoserine.
 MOD_RES 331 331 Phosphothreonine.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD RREEAHWNRQ 60
QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY LKRKGSTSPE PTKGSSRSGS 120
GNNSRFMSFS DMVRGQADDD DEDQPRNTFA GGETSGLEVT DPSDPNSLLK DLLEKARRGG 180
QMGAENGFRD DEDHEMGANR FTGRGFRLGS TIDAADEVVE DNTSQSQRRP EKVTREITFW 240
KEGFQVADGP LYRYDDPANS FYLSELNQGR APLKLLDVQF GQEVEVNVYK KLDESYKAPT 300
RKLGGFSGQG QRLGSPIPGE SSPAEVPKNE TPAAQEQPMP DNEPKQGDTS IQIRYANGKR 360
EVLHCNSTDT VKFLYEHVTS NANTDPSRNF TLNYAFPIKP ISNDETTLKD ADLLNSVVVQ 420
RWA 423 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0008599; F:protein phosphatase type 1 regulator activity; IMP:SGD.
 GO:0030437; P:ascospore formation; IMP:SGD.
 GO:0000045; P:autophagic vacuole assembly; IMP:SGD.
 GO:0030433; P:ER-associated protein catabolic process; IMP:SGD.
 GO:0005977; P:glycogen metabolic process; IMP:SGD.
 GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD.
 GO:0031134; P:sister chromatid biorientation; IMP:SGD. 
Interpro
 IPR012989; SEP_domain.
 IPR009060; UBA-like.
 IPR001012; UBX. 
Pfam
 PF08059; SEP
 PF00789; UBX 
SMART
 SM00553; SEP
 SM00166; UBX 
PROSITE
 PS51399; SEP
 PS50033; UBX 
PRINTS