CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013663
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat domain-containing protein 36C 
Protein Synonyms/Alias
 Protein immuno-reactive with anti-PTH polyclonal antibodies 
Gene Name
 ANKRD36C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
241EDYASEAKNRVIFELubiquitination[1]
1070LKATGDEKDSVSNIAubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
 REPEAT 64 93 ANK 1.
 REPEAT 97 126 ANK 2.
 REPEAT 130 159 ANK 3.
 REPEAT 163 192 ANK 4.
 REPEAT 196 225 ANK 5.  
Keyword
 Alternative splicing; ANK repeat; Coiled coil; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1778 AA 
Protein Sequence
MDDKEPKRWP TLRDRLCSDG FLFPQYPIKP YHLKGIHRAV FYRDLEELKF VLLTRYDINK 60
RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT PLIKAVQLRQ EACATLLLQN 120
GADPNITDVF GRTALHYAVY NEDTSMIEKL LSYGANIEEC SEDEYPPLFL AVSQRKVKMV 180
EFLLKKKANI NAVDYLGRSA LIHAVTLGEK DIVILLLQHN IDVFSRDVYG KLAEDYASEA 240
KNRVIFELIY EYERKKHEEL SINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT 300
VSSQKQPALK GTSDKNDSVS NTATEIKDEQ KSGTVSSQKQ PALKDTSDKN DSVSNTATEI 360
KDEQKSGTVL PAVEQCLNRS LYRPDAVAQP VTEDEFALES EIISKLYIPK RKIISPRSIE 420
DVLPPVEEAV DRCLYLLDRF AQAVTKDKFA LESENISEPY FTNRRTISQQ SAEKLDAACG 480
IDKTENGTLF EDQNVDKEGK ALPATGQKAN VSPEQPPLFT HTVKDSDHIS TRFLGSMDSL 540
TSSEESSERP PLSTLTLKEA DPSSKAAMRR KDSPPPGKVS SQKQPAEKAT SDDKDSVSNI 600
ATEIKEGPIS GTVSSQKQPA EKATSDEKDS VSNIATEIKE GQQSGTVSPQ KQSAWKVIFK 660
KKVSLLNIAT RITGGGKSGT VSSQKQPPSK ATSDKTDSAL NIATEIKDGL QCGTVSSQKQ 720
PALKATTDEE DSVSNIATEI KDGEKSGTVS SQKQPALKAT TDEEDSVSII ATEIKDGEKS 780
GTVSSRKKPA LKATSDEKDS FSNITREKKD GEISRTVTSE KPAGLKATSD EEDSVLNIAR 840
GKEDGEKTRR VSSRKKPALK ATSDEKDSFS NITREKKDGE TSRTVSSQKP PALKATSDEE 900
DSVLNIAREK KDGEKSRTVS SEKPSGLKAT SDEKDSVLNI ARGKKHGEKT RRVSSHKQPA 960
LKATSDKENS VPNMATETKD EQISGTVSSQ KQPALKATSD KKDSVSNIPT EIKDGQQSGT 1020
VSSQKQLAWK ATSVKKDSVS NIATEIKDGQ IRGTVSSQRQ PALKATGDEK DSVSNIAREI 1080
KDGEKSGTVS PQKQSAQKVI FKKKVSLLNI ATRITGGWKS GTEYPENLPT LKATIENKNS 1140
VLNTATKMKD VQTSTPEQDL EMASEGEQKR LEEYENNQPQ VKNQIHSRDD LDDIIQSSQT 1200
VSEDGDSLCC NCKNVILLID QHEMKCKDCV HLLKIKKTFC LCKRLTELKD NHCEQLRVKI 1260
RKLKNKASVL QKRLSEKEEI KSQLKHETLE LEKELCSLRF AIQQEKKKRR NVEELHQKVR 1320
EKLRITEEQY RIEADVTKPI KPALKSAEVE LKTGGNNSNQ VSETDEKEDL LHENRLMQDE 1380
IARLRLEKDT IKNQNLEKKY LKDFEIVKRK HEDLQKALKR NEETLAETIA CYSGQLAALT 1440
DENTTLRSKL EKQRESGQRL ETEMQSYRCR LNAALCDHDQ SHSSKRDQEL AFQGTVDKCC 1500
HLQENLNSHV LILSLQLSKA ESKFRVLETE LHYTGEALKE KALVFEHVQS ELKQKQSQMK 1560
DIEKMYKSGY NTMEKCIEKQ ERFCQLKKQN MLLQQQLDDA RNKADNQEKA ILNIQARCDA 1620
RVENLQAECR KHRLLLEEDN KMLVNELNHS KEKKCQYEKE KAEREVAVRQ LQQKQDDVLN 1680
KRSATKALLD ASSRHCIYLE NGMQDSRKKL DQMRSQFQEI QDQLTATIRC TKEMEGDAQK 1740
LEVENVMMRK IIKKQDEQIE RFEKILQHSS LMLQVFES 1778 
Gene Ontology
 GO:0008200; F:ion channel inhibitor activity; NAS:UniProtKB. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS