CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037930
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase MLL 
Protein Synonyms/Alias
  
Gene Name
 KMT2A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
310IKKLRAGKLSPLKSKubiquitination[1]
322KSKFKTGKLQIGRKGubiquitination[1]
359LINSELEKPQKVRKDacetylation[2]
678AKEGLIRKPIFDNFRubiquitination[3]
1163EPLAPPIKPIKPVTRacetylation[4, 5]
1166APPIKPIKPVTRNKAacetylation[4]
1268SKESSVVKNVVDSSQacetylation[2]
1276NVVDSSQKPTPSAREacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1439 AA 
Protein Sequence
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG PGAPPSPPAV 60
AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS SGPALLRVGP GFDAALQVSA 120
AIGTNLRRFR AVFGESGGGG GSGELTTQIP CSWRTKGHIH DKKTEPFRLL AWSWCLNDEQ 180
FLGFGSDEEV RVRSPTRSPS VKTSPRKPRG RPRSGSDRNS AILSDPSVFS PLNKSETKSG 240
DKIKKKDSKS IEKKRGRPPT FPGVKIKITH GKDISELPKG NKEDSLKKIK RTPSATFQQA 300
TKIKKLRAGK LSPLKSKFKT GKLQIGRKGV QIVRRRGRPP STERIKTPSG LLINSELEKP 360
QKVRKDKEGT PPLTKEDKTV VRQSPRRIKP VRIIPSSKRT DATIAKQLLQ RAKKGAQKKI 420
EKEAAQLQGR KVKTQVKNIR QFIMPVVSAI SSRIIKTPRR FIEDEDYDPP IKIARLESTP 480
NSRFSAPSCG SSEKSSAASQ HSSQMSSDSS RSSSPSVDTS TDSQASEEIQ VLPEERSDTP 540
EVHPPLPISQ SPENESNDRR SRRYSVSERS FGSRTTKKLS TLQSAPQQQT SSSPPPPLLT 600
PPPPLQPASS ISDHTPWLMP PTIPLASPFL PASTAPMQGK RKSILREPTF RWTSLKHSRS 660
EPQYFSSAKY AKEGLIRKPI FDNFRPPPLT PEDVGFASGF SASGTAASAR LFSPLHSGTR 720
FDMHKRSPLL RAPRFTPSEA HSRIFESVTL PSNRTSAGTS SSGVSNRKRK RKVFSPIRSE 780
PRSPSHSMRT RSGRLSSSEL SPLTPPSSVS SSLSISVSPL ATSALNPTFT FPSHSLTQSG 840
ESAEKNQRPR KQTSAPAEPF SSSSPTPLFP WFTPGSQTER GRNKDKAPEE LSKDRDADKS 900
VEKDKSRERD REREKENKRE SRKEKRKKGS EIQSSSALYP VGRVSKEKVV GEDVATSSSA 960
KKATGRKKSS SHDSGTDITS VTLGDTTAVK TKILIKKGRG NLEKTNLDLG PTAPSLEKEK 1020
TLCLSTPSSS TVKHSTSSIG SMLAQADKLP MTDKRVASLL KKAKAQLCKI EKSKSLKQTD 1080
QPKAQGQESD SSETSVRGPR IKHVCRRAAV ALGRKRAVFP DDMPTLSALP WEEREKILSS 1140
MGNDDKSSIA GSEDAEPLAP PIKPIKPVTR NKAPQEPPVK KGRRSRRCGQ CPGCQVPEDC 1200
GVCTNCLDKP KFGGRNIKKQ CCKMRKCQNL QWMPSKAYLQ KQAKAVKKKE KKSKTSEKKD 1260
SKESSVVKNV VDSSQKPTPS AREDPAPKKS SSEPPPRKPV EEKSEEGNVS APGPESKQAT 1320
TPASRKSSKQ VSQPALVIPP QPPTTGPPRK EVPKTTPSEP KKKQPPPPES GPEQSKQKKV 1380
APRPSIPVKQ KPKEKEKPPP VNKQENAGTL NILSTLSNGN SSKQKIPADG VHRIRVDFK 1439 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR002857; Znf_CXXC. 
Pfam
 PF02008; zf-CXXC 
SMART
 SM00384; AT_hook 
PROSITE
 PS51058; ZF_CXXC 
PRINTS