| Tag | Content |
|---|
| CPLM ID | CPLM-018438 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RNA polymerase-associated protein RapA |
Protein Synonyms/Alias | ATP-dependent helicase HepA |
Gene Name | rapA |
Gene Synonyms/Alias | hepA; STM0096 |
Created Date | July 27, 2013 |
Organism | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
NCBI Taxa ID | 99287 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 615 | IHVPYLEKTAQSVLV | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity). |
Sequence Annotation | DOMAIN 164 334 Helicase ATP-binding.
DOMAIN 490 685 Helicase C-terminal.
NP_BIND 177 184 ATP (By similarity).
MOTIF 280 283 DEAH box. |
Keyword | Activator; ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 968 AA |
Protein Sequence | MPFTLGQRWI SDTESELGLG TVVAMDARTV TLLFPSTGEN RLYARSDSPV TRVMFNPGDT 60
ITSHEGWQLH IDEVKEENGL LVYVGTRLDT EETNVTLREV LLDSKLVFSK PQDRLFAGQI 120
DRMDRFALRY RARKFQSEQY RMPYSGLRGQ RTNLIPHQLN IAHDVGRRHA PRVLLADEVG 180
LGKTIEAGMI LHQQLLSGAA ERVLIIVPET LQHQWLVEML RRFNLRFALF DDERYTEAQH 240
DAYNPFETEQ LVICSLDFAR RNKQRLEHLC DAEWDLLVVD EAHHLVWSTD APSREYMAIE 300
QLAERVPGVL LLTATPEQLG MESHFARLRL LDPNRFHDFE QFVEEQKNYR PVADAVAMLL 360
AGNKLSNDEL NRLGDLIGEQ DIEPLLQAAN SDRDDAQAAR DELVSMLMDR HGTSRVLFRN 420
TRNGVKGFPK RELHTVKLPL PTQYQTAIKV SGIMGARKSP EDRARDMLYP EQIYQEFEGD 480
TGTWWNFDPR VEWLMGYLTS HRSQKVLVIC AKATTALQLE QVLREREGIR AAVFHEGMSI 540
IERDRAAAWF AEEDTGAQVL LCSEIGSEGR NFQFASNLVM FDLPFNPDLL EQRIGRLDRI 600
GQAHDIQIHV PYLEKTAQSV LVRWYHEGLD AFEHTCPTGR AIYDSAYASL INYLAAPEET 660
DGFDDLIKSC REQHEALKAQ LEQGRDRLLE IHSNGGEKAQ QLAQSIEEQD DDTNLIAFAM 720
NLFDIVGINQ DDRGDNLIVL TPSDHMLVPD FPGLPEDGCT ITFERDVALS REDAQFITWE 780
HPLIRNGLDL ILSGDTGSST ISLLKNKALP VGTLLVELVY VVEAQAPKQL QLNRFLPPTP 840
VRMLLDKNGN NLAAQVEFET FNRQLSAVNR HTGSKLVNAV QQDVHAILQL GETQIEKSAR 900
ALIDNARREA DEKLSGELSR LEALRAVNPN IRDDELAAID SNRQQVLESL NQAGWRLDAL 960
RLIVVTHQ 968 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:HAMAP. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0004386; F:helicase activity; IEA:HAMAP. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:HAMAP. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
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