UniProt Accession

 CINP_HUMAN; Q9BW66; F5H7P3; F5H8A7; Q9NPF9 

Genbank Protein ID

 AF228148; AF228149; AK056112; DA167716; CR457178; AL137229; CH471061; BC000600; BU174070 

Genbank Nucleotide ID

 AAF44747.1; AAF44748.1; BAB71095.1; CAG33459.1; EAW81785.1; AAH00600.1 

Protein Name

 Cyclin-dependent kinase 2-interacting protein 

Protein Synonyms/Alias

 CDK2-interacting protein 

Gene Name

 CINP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MEAKTLGTVTP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; DNA damage; DNA repair; DNA replication; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 

Interpro

 IPR023250; Cyclin-dep_Kinase_2_interact. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02040; CDK2IP.