UniProt Accession

 KCC2G_HUMAN; Q13555; O00561; O15378; Q13279; Q13282; Q13556; Q5SQZ3; Q5SQZ4; Q5SWX4; Q7KYX5; Q8N4I3; Q8NIA4 

Genbank Protein ID

 AL713896; AC022400; AL596247; AL713896; AC022400; AL596247; AL713896; AC022400; AL596247; AL596247; AC022400; AL713896; AL596247; AC022400; AL713896; AL596247; AC022400; AL713896; CH471083; CH471083; BC034044; U66064; AH011636; L07043; U50359; U50360; U32472; U32473; U32509 

Genbank Nucleotide ID

 CAI13789.1; CAI13789.1; CAI13789.1; CAI13790.1; CAI13790.1; CAI13790.1; CAI13791.1; CAI13791.1; CAI13791.1; CAI13965.1; CAI13965.1; CAI13965.1; CAI13966.1; CAI13966.1; CAI13966.1; CAI13968.1; CAI13968.1; CAI13968.1; EAW54532.1; EAW54536.1; AAH34044.1; AAB80848.1; AAM33514.1; AAB61379.1; AAB16864.1; AAB16865.1; AAA75201.1; AAA75202.1; AAA75203.1 

Protein Name

 Calcium/calmodulin-dependent protein kinase type II subunit gamma 

Protein Synonyms/Alias

 CaM kinase II subunit gamma; CaMK-II subunit gamma 

Gene Name

 CAMK2G 

Gene Synonyms/Alias

 CAMK; CAMK-II; CAMKG 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	ARICRLLKHPNIVRL	ubiquitination	[1]
138	DIVHRDLKPENLLLA	ubiquitination	[1, 2]
147	ENLLLASKCKGAAVK	ubiquitination	[1]
259	MLTINPAKRITADQA	ubiquitination	[1]
268	ITADQALKHPWVCQR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. 

Sequence Annotation

 DOMAIN 14 272 Protein kinase.
 NP_BIND 20 28 ATP (By similarity).
 REGION 283 292 Autoinhibitory domain.
 REGION 291 301 Calmodulin-binding (By similarity).
 REGION 294 316 Calmodulin-binding.
 ACT_SITE 136 136 Proton acceptor (By similarity).
 BINDING 43 43 ATP (By similarity).
 MOD_RES 235 235 Phosphoserine (By similarity).
 MOD_RES 287 287 Phosphothreonine; by autocatalysis.
 MOD_RES 306 306 Phosphothreonine; by autocatalysis (By
 MOD_RES 307 307 Phosphothreonine; by autocatalysis
 MOD_RES 311 311 Phosphoserine.
 MOD_RES 349 349 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 419 419 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Sarcoplasmic reticulum; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; NAS:UniProtKB.
 GO:0004723; F:calcium-dependent protein serine/threonine phosphatase activity; NAS:UniProtKB.
 GO:0005516; F:calmodulin binding; NAS:UniProtKB.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0030073; P:insulin secretion; NAS:UniProtKB.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0006468; P:protein phosphorylation; NAS:UniProtKB.
 GO:0051924; P:regulation of calcium ion transport; TAS:UniProtKB.
 GO:0014733; P:regulation of skeletal muscle adaptation; TAS:UniProtKB.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR013543; Ca/CaM-dep_prot_kinase-assoc.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF08332; CaMKII_AD
 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS