UniProt Accession

 H31_CHLRE; Q42681 

Genbank Protein ID

 U16825 

Genbank Nucleotide ID

 AAA98455.1 

Protein Name

 Histone H3 type 1 

Protein Synonyms/Alias

  

Gene Name

 ch3-I 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Chlamydomonas reinhardtii (Chlamydomonas smithii) 

NCBI Taxa ID

 3055 

Lysine Modification

Position	Peptide	Type	References
10	RTKQTARKSTGGKAP	acetylation	[1]
15	ARKSTGGKAPRKQLA	acetylation	[1]
19	TGGKAPRKQLATKAA	acetylation	[1]
24	PRKQLATKAARKTPA	acetylation	[1]
28	LATKAARKTPATGGV	acetylation	[1]

Reference

 [1] Histones of Chlamydomonas reinhardtii. Synthesis, acetylation, and methylation.
 Waterborg JH, Robertson AJ, Tatar DL, Borza CM, Davie JR.
 Plant Physiol. 1995 Oct;109(2):393-407. [PMID: 7480339] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 5 5 N6-methyllysine.
 MOD_RES 10 10 N6-acetyllysine; alternate.
 MOD_RES 10 10 N6-methyllysine; alternate.
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 12 12 Phosphothreonine (By similarity).
 MOD_RES 15 15 N6-acetyllysine.
 MOD_RES 19 19 N6-acetyllysine.
 MOD_RES 24 24 N6-acetyllysine.
 MOD_RES 28 28 N6-acetyllysine; alternate.
 MOD_RES 28 28 N6-methyllysine; alternate.
 MOD_RES 36 36 N6-methyllysine.
 MOD_RES 37 37 N6-methyllysine.  

Keyword

 Acetylation; Chromosome; Direct protein sequencing; DNA-binding; Methylation; Nucleosome core; Nucleus; Phosphoprotein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 135 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000164; Histone_H3. 

Pfam

 PF00125; Histone 

SMART

 SM00428; H3 

PROSITE

 PS00322; HISTONE_H3_1
 PS00959; HISTONE_H3_2 

PRINTS

 PR00622; HISTONEH3.