UniProt Accession

 TIPIN_HUMAN; Q9BVW5; B2CW64; Q9NWZ6 

Genbank Protein ID

 AK000523; EU551725; AC055855; CH471082; BC000870; BK001386 

Genbank Nucleotide ID

 BAA91229.1; ACB21044.1; EAW77762.1; AAH00870.1; DAA01365.1 

Protein Name

 TIMELESS-interacting protein 

Protein Synonyms/Alias

  

Gene Name

 TIPIN 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	DKAKFKGKGHEAEDL	ubiquitination	[1]
101	GHEAEDLKMLIRHME	ubiquitination	[1, 2]
117	WAHRLFPKLQFEDFI	ubiquitination	[2]
133	RVEYLGSKKEVQTCL	ubiquitination	[1, 3]
134	VEYLGSKKEVQTCLK	ubiquitination	[1]
207	QQRIERNKQLALERR	ubiquitination	[1]
217	ALERRQAKLLSNSQT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. 

Sequence Annotation

 REGION 67 143 Interaction with TIMELESS.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 244 244 Phosphothreonine.  

Keyword

 Cell cycle; Cell division; Complete proteome; Cytoplasm; DNA damage; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0000790; C:nuclear chromatin; IDA:HGNC.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000076; P:DNA replication checkpoint; IMP:HGNC.
 GO:0031573; P:intra-S DNA damage checkpoint; IMP:HGNC.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0008284; P:positive regulation of cell proliferation; IMP:HGNC.
 GO:0033262; P:regulation of nuclear cell cycle DNA replication; TAS:HGNC.
 GO:0048478; P:replication fork protection; IEA:InterPro.
 GO:0009411; P:response to UV; IEA:Compara. 

Interpro

 IPR012923; Swi3. 

Pfam

 PF07962; Swi3 

SMART

  

PROSITE

  

PRINTS