CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043738
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 3-hydroxyisobutyrate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 HIBADH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38SPADVAEKADRIITMubiquitination[1]
84TIDPAVSKELAKEVEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 206 AA 
Protein Sequence
XELPHTLKLP GLPLFPNKFL ISLVLLILVS SPADVAEKAD RIITMLPTSI NAIEAYSGAN 60
GILKKVKKGS LLIDSSTIDP AVSKELAKEV EKMGAVFMDA PVSGGVGAAR SGNLTFMVGG 120
VEDEFAAAQE LLGCMGSNVV YCGAVGTGQA AKICNNMLLA ISMIGTAEAM NLGIRLGLDP 180
KLLAKILNMS SGRCWSSDTY NPVPGV 206 
Gene Ontology
 GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
 GO:0006098; P:pentose-phosphate shunt; IEA:InterPro. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR006115; 6PGDH_NADP-bd.
 IPR013328; DH_multihelical.
 IPR015815; HIBADH-type.
 IPR011548; IsoBut3OH_DH.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF03446; NAD_binding_2 
SMART
  
PROSITE
  
PRINTS