UniProt Accession

 PRPS2_HUMAN; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7 

Genbank Protein ID

 Y00971; BC030019; BC040483; BC110875; BC119662; BC119663; D28134 

Genbank Nucleotide ID

 CAA68785.1; AAH30019.2; AAH40483.3; AAI10876.2; AAI19663.1; AAI19664.1; BAA05676.1 

Protein Name

 Ribose-phosphate pyrophosphokinase 2 

Protein Synonyms/Alias

 PPRibP; Phosphoribosyl pyrophosphate synthase II; PRS-II 

Gene Name

 PRPS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
179	SPDAGGAKRVTSIAD	ubiquitination	[1]
215	MVLVGDVKDRVAILV	ubiquitination	[2, 3]
283	NTIPQEDKMKHCTKI	ubiquitination	[1]
285	IPQEDKMKHCTKIQV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. 

Sequence Annotation

 NP_BIND 96 101 ATP (By similarity).
 REGION 212 227 Binding of phosphoribosylpyrophosphate
 METAL 128 128 Magnesium (Potential).
 METAL 130 130 Magnesium (Potential).
 METAL 139 139 Magnesium (Potential).
 METAL 143 143 Magnesium (Potential).
 BINDING 130 130 ATP (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0002189; C:ribose phosphate diphosphokinase complex; IEA:Compara.
 GO:0043531; F:ADP binding; IEA:Compara.
 GO:0016208; F:AMP binding; IEA:Compara.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0030246; F:carbohydrate binding; IEA:Compara.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0004749; F:ribose phosphate diphosphokinase activity; ISS:UniProtKB.
 GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006167; P:AMP biosynthetic process; IEA:Compara.
 GO:0006139; P:nucleobase-containing compound metabolic process; TAS:ProtInc.
 GO:0031100; P:organ regeneration; IEA:Compara. 

Interpro

 IPR000842; PRib_PP_synth_CS.
 IPR000836; PRibTrfase_dom.
 IPR005946; Rib-P_diPkinase. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00114; PRPP_SYNTHASE 

PRINTS