UniProt Accession

 RING1_MOUSE; O35730; Q3U242; Q3U333; Q4FK33; Q63ZX8; Q921Z8 

Genbank Protein ID

 Y12881; AF100956; AK154962; AK155509; CT010219; BC009070; BC082771 

Genbank Nucleotide ID

 CAA73381.1; AAC69901.1; BAE32956.1; BAE33300.1; CAJ18427.1; AAH09070.1; AAH82771.1 

Protein Name

 E3 ubiquitin-protein ligase RING1 

Protein Synonyms/Alias

 Polycomb complex protein RING1; RING finger protein 1; Transcription repressor Ring1A 

Gene Name

 Ring1 

Gene Synonyms/Alias

 Ring1A; Rnf1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
285	YCQTRYVKTTGNATV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity). 

Sequence Annotation

 ZN_FING 48 88 RING-type.
 REGION 30 234 Necessary for transcriptional repression.
 REGION 230 406 Necessary for interaction with CBX2.
 MOTIF 201 204 Nuclear localization signal (By
 MOD_RES 38 38 Phosphoserine (By similarity).
 MOD_RES 140 140 Phosphoserine (By similarity).
 MOD_RES 187 187 Phosphoserine (By similarity).
 MOD_RES 190 190 Phosphoserine (By similarity).
 MOD_RES 248 248 Phosphoserine (By similarity).
 MOD_RES 254 254 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Chromatin regulator; Complete proteome; Ligase; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0016604; C:nuclear body; IDA:MGI.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0031519; C:PcG protein complex; IDA:MGI.
 GO:0035102; C:PRC1 complex; IEA:Compara.
 GO:0001739; C:sex chromatin; IDA:MGI.
 GO:0000151; C:ubiquitin ligase complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0048593; P:camera-type eye morphogenesis; IGI:MGI.
 GO:0035518; P:histone H2A monoubiquitination; IEA:Compara.
 GO:0016574; P:histone ubiquitination; IDA:MGI.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 

Pfam

 PF00097; zf-C3HC4 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS