UniProt Accession

 GREA_MYCPN; P78019 

Genbank Protein ID

 U00089 

Genbank Nucleotide ID

 AAB96085.1 

Protein Name

 Transcription elongation factor GreA 

Protein Synonyms/Alias

 Transcript cleavage factor GreA 

Gene Name

 greA 

Gene Synonyms/Alias

 MPN_401; MP437 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
54	NADYDAAKAQQGEIE	acetylation	[1]
83	LINESQTKKANKVTL	acetylation	[1]
156	PYRVKIVKIINW***	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity). 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; DNA-binding; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0032784; P:regulation of DNA-dependent transcription, elongation; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR018151; TF_GreA/GreB_CS.
 IPR006359; Tscrpt_elong_fac_GreA.
 IPR023459; Tscrpt_elong_fac_GreA/B.
 IPR001437; Tscrpt_elong_fac_GreA/B_C.
 IPR022691; Tscrpt_elong_fac_GreA/B_N. 

Pfam

 PF01272; GreA_GreB
 PF03449; GreA_GreB_N 

SMART

  

PROSITE

 PS00829; GREAB_1
 PS00830; GREAB_2 

PRINTS