CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005408
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTPase HflX 
Protein Synonyms/Alias
 GTP-binding protein HflX 
Gene Name
 hflX 
Gene Synonyms/Alias
 b4173; JW4131 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
55SRKAPHPKYFVGEGKacetylation[1]
121RARTHEGKLQVELAQacetylation[1]
268HDLVAAFKATLQETRacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. In vitro, also exhibits ATPase activity. 
Sequence Annotation
 DOMAIN 209 318 G.
 NP_BIND 204 212 GTP (By similarity).
 NP_BIND 317 320 GTP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 426 AA 
Protein Sequence
MFDRYDAGEQ AVLVHIYFTQ DKDMEDLQEF ESLVSSAGVE ALQVITGSRK APHPKYFVGE 60
GKAVEIAEAV KATGASVVLF DHALSPAQER NLERLCECRV IDRTGLILDI FAQRARTHEG 120
KLQVELAQLR HLATRLVRGW THLERQKGGI GLRGPGETQL ETDRRLLRNR IVQIQSRLER 180
VEKQREQGRQ SRIKADVPTV SLVGYTNAGK STLFNRITEA RVYAADQLFA TLDPTLRRID 240
VADVGETVLA DTVGFIRHLP HDLVAAFKAT LQETRQATLL LHVIDAADVR VQENIEAVNT 300
VLEEIDAHEI PTLLVMNKID MLEDFEPRID RDEENKPNRV WLSAQTGAGI PQLFQALTER 360
LSGEVAQHTL RLPPQEGRLR SRFYQLQAIE KEWMEEDGSV SLQVRMPIVD WRRLCKQEPA 420
LIDYLI 426 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0005524; F:ATP binding; IDA:EcoliWiki.
 GO:0005525; F:GTP binding; IDA:EcoCyc.
 GO:0003924; F:GTPase activity; IEA:HAMAP.
 GO:0043022; F:ribosome binding; IDA:EcoCyc.
 GO:0019843; F:rRNA binding; IDA:EcoCyc.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0009408; P:response to heat; IEP:EcoliWiki. 
Interpro
 IPR009022; EFG_III-V.
 IPR006073; GTP_binding_domain.
 IPR016496; GTPase_HflX.
 IPR025121; GTPase_HflX_N_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF13167; GTP-bdg_N
 PF01926; MMR_HSR1 
SMART
  
PROSITE
  
PRINTS
 PR00326; GTP1OBG.