CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016141
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 26B1 
Protein Synonyms/Alias
 Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450RAI-2 
Gene Name
 Cyp26b1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
407HDTAPVFKDVNVFDPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. 
Sequence Annotation
 METAL 441 441 Iron (heme axial ligand) (Potential).  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 512 AA 
Protein Sequence
MLFEGLELVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP KGSMGFPLIG 60
ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE NVRKILLGEH QLVSTEWPRS 120
ARVLLGPNTV ANSIGDIHRN KRKVFSKIFS HEALESYLPK IQLVIQDTLR AWSSQPEAIN 180
VYQEAQRLTF RMAVRVLLGF SIPEEDLGHL FEVYQQFVEN VFSLPVDLPF SGYRRGIQAR 240
QILQKGLEKA IREKLQCTQG KDYSDALDIL IESSKEHGKE MTMQELKDGT LELIFAAYAT 300
TASASTSLIM QLLKHPAVLE KLREELRAQG LLHGGGCPCE GTLRLDTLSS LRYLDCVIKE 360
VMRLFTPVSG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH DTAPVFKDVN VFDPDRFSQA 420
RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF LKVLAVELAS TSRFELATRT FPRITLVPVL 480
HPVDGLSVKF FGLDSNQNEI LPETEAMLSA TV 512 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0008401; F:retinoic acid 4-hydroxylase activity; IEA:Compara.
 GO:0001972; F:retinoic acid binding; IEA:Compara.
 GO:0060349; P:bone morphogenesis; IEA:Compara.
 GO:0001709; P:cell fate determination; IMP:MGI.
 GO:0071300; P:cellular response to retinoic acid; IEP:UniProtKB.
 GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.
 GO:0007140; P:male meiosis; IMP:MGI.
 GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
 GO:2001037; P:positive regulation of tongue muscle cell differentiation; IMP:UniProtKB.
 GO:0009954; P:proximal/distal pattern formation; IMP:MGI.
 GO:0034653; P:retinoic acid catabolic process; IEA:Compara.
 GO:0042573; P:retinoic acid metabolic process; IC:MGI.
 GO:0048384; P:retinoic acid receptor signaling pathway; IMP:UniProtKB.
 GO:0007283; P:spermatogenesis; IMP:MGI.
 GO:0043587; P:tongue morphogenesis; IMP:UniProtKB. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002403; Cyt_P450_E_grp-IV. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00465; EP450IV.
 PR00385; P450.