| Tag | Content |
|---|
| CPLM ID | CPLM-022642 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein kinase C and casein kinase substrate in neurons 2 protein |
Protein Synonyms/Alias | Synaptic dynamin-associated protein II; Syndapin 2; Syndapin-II; SdpII |
Gene Name | Pacsin2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 117 | EKIKNWQKEAFHKQM | acetylation | [1] | | 150 | KPWAKKLKEVDAAKK | acetylation | [1] | | 275 | RELEQSIKAADAVED | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus (By similarity). |
Sequence Annotation | DOMAIN 11 75 FCH.
DOMAIN 428 488 SH3.
REGION 1 308 F-BAR domain (By similarity). |
Keyword | Alternative splicing; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endocytosis; Endosome; Lipid-binding; Membrane; Phosphoprotein; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 488 AA |
Protein Sequence | MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCGD LMNCLHERAR IEKAYAQQLT 60
EWARRWRQLV EKGPQYGTVE KAWMAVMSEA ERVSELHLEV KASLMNEDFE KIKNWQKEAF 120
HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVDAAKKAHH TACKEEKLAV SREANSKADP 180
SLNPEQLKKL QDKIEKCKQD VLKTKDKYEK ALKELDQTTP QYMENMEQVF EQCQQFEEKR 240
LRFFREVLLE VQKHLDLSNV ASYKGIYREL EQSIKAADAV EDLRWFRANH GPGMAMNWPQ 300
FEDEEWSADL NRTLSRREKK KAADGVTLTG INQTGDQSGQ NKPSSNLSVP SNPAQSTQLQ 360
SSYNPFEDED DTGSSVSEKE DIKAKNVSSY EKTQNYPADW SDDESNNPFS STDANGDSNP 420
FDEDTTSGTE VRVRALYDYE GQEHDELSFK AGDELTKIED EDEQGWCKGR LDSGQVGLYP 480
ANYVEAIQ 488 |
Gene Ontology | GO:0005901; C:caveola; IEA:UniProtKB-SubCell. GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; IEA:Compara. GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. GO:0019898; C:extrinsic to membrane; ISS:UniProtKB. GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. GO:0008289; F:lipid binding; IEA:UniProtKB-KW. GO:0070836; P:caveola assembly; ISS:UniProtKB. GO:0072584; P:caveolin-mediated endocytosis; ISS:UniProtKB. GO:0048858; P:cell projection morphogenesis; ISS:UniProtKB. GO:0097320; P:membrane tubulation; ISS:UniProtKB. GO:0045806; P:negative regulation of endocytosis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |