CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020847
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peptidyl-prolyl cis-trans isomerase-like 2 
Protein Synonyms/Alias
 PPIase; Cyclophilin-60; Cyclophilin-like protein Cyp-60; Rotamase PPIL2 
Gene Name
 Ppil2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
86TGEKLDGKSLIKLNFubiquitination[1]
90LDGKSLIKLNFAKNSubiquitination[1]
483TYRQGVGKYIHPAATacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). 
Sequence Annotation
 DOMAIN 42 101 U-box.
 DOMAIN 278 433 PPIase cyclophilin-type.
 MOD_RES 483 483 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; Isomerase; Nucleus; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 521 AA 
Protein Sequence
MGKRQHQKDK MYITCAEYTH FYGGRKPDIS QTSFRRLPFD HCSLSLQPFV YPVCTPEGVV 60
FDLLNIVPWL KKYGTNPSTG EKLDGKSLIK LNFAKNSEGQ YHCPVLYSVF TDNTHIVAIR 120
TTGNVYTYEA VEQLNIKAKN LRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFFHVKNNMR 180
IIDPDEEKAK QDPSYYLKNT NSETRETLQE LYKEFKGDEI LAATMRPPEK KKVDQLNAAH 240
YSTGKVSASF TSTAMVPETT HEAAVIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT 300
PKTCENFIKL CKKQYYDGTI FHRSIRNFVI QGGDPTGTGT GGESFWGKPF KDEFRPNLSH 360
TGRGVLSMAN SGPNTNKSQF FITFRSCAYL DKKHTIFGRV VGGFDTLTAM ENVESDPKTD 420
RPKEEVLICT TTVFVDPYEE ADAQIAQERK KTQHQVDPEA KVKMSQPQPG NQGPQTYRQG 480
VGKYIHPAAT KRSAEEEPST STATPTAKKR PSRGFGDFSS W 521 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:Compara.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0000209; P:protein polyubiquitination; IEA:Compara. 
Interpro
 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS.
 IPR026951; PPIL2.
 IPR003613; Ubox_domain.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00160; Pro_isomerase 
SMART
 SM00504; Ubox 
PROSITE
 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 
PRINTS
 PR00153; CSAPPISMRASE.