CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022876
UniProt Accession
Genbank Protein ID
 L27476; AF177533; AF043195; AF043196; AF043197; AF177518; AF177519; AF177520; AF177521; AF177522; AF177523; AF177524; AF177525; AF177526; AF177527; AF177528; AF177529; AF177530; AF177531; AF177532; AF177533; AF043196; AF043197; AF177518; AF177519; AF177520; AF177521; AF177522; AF177523; AF177524; AF177525; AF177526; AF177527; AF177528; AF177529; AF177530; AF177531; AF177532; AF177533; AF043195; AF043196; AF043197; AF177518; AF177519; AF177520; AF177521; AF177522; AF177523; AF177524; AF177525; AF177526; AF177527; AF177528; AF177529; AF177532; AF177533; AF043196; AF043197; AF177518; AF177519; AF177520; AF177521; AF177522; AF177523; AF177524; AF177525; AF177526; AF177527; AF177528; AF177529; AF177532; AF489824; AK295034; AK302483; AL162730; AL358113; AL358113; AL358113; AL590238; BC027592; AF083892; AF083893; U84581 
Genbank Nucleotide ID
 AAA61300.1; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAD20387.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAC02527.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56218.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAD56219.2; AAM28524.1; BAH11954.1; BAH13722.1; CAH70867.1; CAH70868.1; CAM13389.1; AAH27592.1; AAC33121.1; AAC33122.1; AAB41794.1 
Protein Name
 Tight junction protein ZO-2 
Protein Synonyms/Alias
 Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2 
Gene Name
 TJP2 
Gene Synonyms/Alias
 X104; ZO2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
475TVVPETNKEPRYQEDubiquitination[1]
1016FSKSYEYKSNPSAVAubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Plays a role in tight junctions and adherens junctions. 
Sequence Annotation
 DOMAIN 33 120 PDZ 1.
 DOMAIN 307 385 PDZ 2.
 DOMAIN 509 590 PDZ 3.
 DOMAIN 604 669 SH3.
 DOMAIN 678 876 Guanylate kinase-like.
 REGION 1188 1190 Interaction with SCRIB.
 MOD_RES 130 130 Phosphoserine.
 MOD_RES 153 153 Phosphoserine.
 MOD_RES 168 168 Phosphoserine.
 MOD_RES 170 170 Phosphoserine.
 MOD_RES 174 174 Phosphoserine.
 MOD_RES 200 200 Phosphoserine.
 MOD_RES 220 220 Phosphoserine.
 MOD_RES 244 244 Phosphoserine.
 MOD_RES 265 265 Phosphotyrosine (By similarity).
 MOD_RES 266 266 Phosphoserine.
 MOD_RES 292 292 Phosphoserine (By similarity).
 MOD_RES 294 294 Phosphoserine (By similarity).
 MOD_RES 296 296 Phosphoserine (By similarity).
 MOD_RES 400 400 Phosphoserine.
 MOD_RES 430 430 Phosphoserine.
 MOD_RES 455 455 Phosphothreonine.
 MOD_RES 702 702 Phosphoserine.
 MOD_RES 920 920 Phosphoserine.
 MOD_RES 925 925 Phosphothreonine.
 MOD_RES 933 933 Phosphothreonine.
 MOD_RES 966 966 Phosphoserine.
 MOD_RES 978 978 Phosphoserine.
 MOD_RES 986 986 Phosphoserine.
 MOD_RES 1006 1006 Phosphoserine (By similarity).
 MOD_RES 1067 1067 Phosphoserine.
 MOD_RES 1068 1068 Phosphoserine.
 MOD_RES 1118 1118 Phosphotyrosine (By similarity).
 MOD_RES 1131 1131 Phosphothreonine.
 MOD_RES 1147 1147 Phosphoserine.
 MOD_RES 1159 1159 Phosphoserine.  
Keyword
 3D-structure; Alternative promoter usage; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Disease mutation; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain; Tight junction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1190 AA 
Protein Sequence
MPVRGDRGFP PRRELSGWLR APGMEELIWE QYTVTLQKDS KRGFGIAVSG GRDNPHFENG 60
ETSIVISDVL PGGPADGLLQ ENDRVVMVNG TPMEDVLHSF AVQQLRKSGK VAAIVVKRPR 120
KVQVAALQAS PPLDQDDRAF EVMDEFDGRS FRSGYSERSR LNSHGGRSRS WEDSPERGRP 180
HERARSRERD LSRDRSRGRS LERGLDQDHA RTRDRSRGRS LERGLDHDFG PSRDRDRDRS 240
RGRSIDQDYE RAYHRAYDPD YERAYSPEYR RGARHDARSR GPRSRSREHP HSRSPSPEPR 300
GRPGPIGVLL MKSRANEEYG LRLGSQIFVK EMTRTGLATK DGNLHEGDII LKINGTVTEN 360
MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPSLNDSDS EIEDISEIES NRSFSPEERR 420
HQYSDYDYHS SSEKLKERPS SREDTPSRLS RMGATPTPFK STGDIAGTVV PETNKEPRYQ 480
EDPPAPQPKA APRTFLRPSP EDEAIYGPNT KMVRFKKGDS VGLRLAGGND VGIFVAGIQE 540
GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADVYRDILA 600
CGRGDSFFIR SHFECEKETP QSLAFTRGEV FRVVDTLYDG KLGNWLAVRI GNELEKGLIP 660
NKSRAEQMAS VQNAQRDNAG DRADFWRMRG QRSGVKKNLR KSREDLTAVV SVSTKFPAYE 720
RVLLREAGFK RPVVLFGPIA DIAMEKLANE LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR 780
QIIEQDKHAL LDVTPKAVDL LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP TSNKSSRKLF 840
DQANKLKKTC AHLFTATINL NSANDSWFGS LKDTIQHQQG EAVWVSEGKM EGMDDDPEDR 900
MSYLTAMGAD YLSCDSRLIS DFEDTDGEGG AYTDNELDEP AEEPLVSSIT RSSEPVQHEE 960
SIRKPSPEPR AQMRRAASSD QLRDNSPPPA FKPEPPKAKT QNKEESYDFS KSYEYKSNPS 1020
AVAGNETPGA STKGYPPPVA AKPTFGRSIL KPSTPIPPQE GEEVGESSEE QDNAPKSVLG 1080
KVKIFEKMDH KARLQRMQEL QEAQNARIEI AQKHPDIYAV PIKTHKPDPG TPQHTSSRPP 1140
EPQKAPSRPY QDTRGSYGSD AEEEEYRQQL SEHSKRGYYG QSARYRDTEL 1190 
Gene Ontology
 GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0004385; F:guanylate kinase activity; TAS:ProtInc.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0035329; P:hippo signaling cascade; TAS:Reactome. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR005417; ZonOcculdens.
 IPR005419; ZonOcculS2. 
Pfam
 PF00625; Guanylate_kin
 PF00595; PDZ
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 
PRINTS
 PR01597; ZONOCCLUDNS.
 PR01599; ZONOCCLUDNS2.