CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013590
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 16 
Protein Synonyms/Alias
  
Gene Name
 Wdr16 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
237LKMNPKTKLLADTGPacetylation[1]
237LKMNPKTKLLADTGPsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
 May play an essential role in the growth or survival of hepatocellular carcinoma (HCC) (By similarity). 
Sequence Annotation
 REPEAT 62 106 WD 1.
 REPEAT 109 150 WD 2.
 REPEAT 156 195 WD 3.
 REPEAT 288 327 WD 4.
 REPEAT 330 369 WD 5.
 REPEAT 372 411 WD 6.
 REPEAT 415 454 WD 7.
 REPEAT 459 498 WD 8.
 REPEAT 500 541 WD 9.
 REPEAT 543 582 WD 10.
 REPEAT 585 620 WD 11.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 620 AA 
Protein Sequence
MEEQVLPELD VAELELQAVI GFNGHVPNGL KCHPDQEHLI YPLGCTVLIQ AINTNEQNFL 60
HGHGNNVSCV TISKEGDYIA SGQVTFMGFK ADIILWDFKK RELIARLSLH KGKIEALAFS 120
PNDLYLVSLG GPDDGSVVVW SIAKRDAICG SPAAGLNVGN ATSVVFSRCR DEMFVTAGNG 180
TIRVWELDLP NRKIWPTECQ TGQMKRIVLS TGMADDDSFF YLGTTTGDIL KMNPKTKLLA 240
DTGPVKDKFS LGVSALRCLK MGGLLVGSGA GLLIFCKSPS YKPIKKVQLQ GGITSITLRG 300
EGHQFFVGTE ESHIYRVNFT DFKETLIATC HFEAVQDIVF PFGTAELFAT CAKKDIRVWH 360
TMSKRELLRI TVPNMTCHGI DFMRDGKSII SAWDDGKIRA FAPESGRLMY TINSAHRIGV 420
TAIATTSDCK RIISGGGEGE VRVWQVGCQT QKLEEALKEH KSSVSCIRVK KNNEECVTAS 480
TDGTCIIWDL VRLRRNQMIL ANTLFQCVCY HPEEFQIITS GTDRKIAYWE VFDGSVIREL 540
EGSLSGSING MDITQEGGHF VTGGHDHLVK VWDYNEGEVT HVGVGHSGNI MAMRISPGNQ 600
YIVSVSADGA ILRWKYPFAS 620 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS